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ADME Study

Known as: ADME, Absorption, Distribution, Metabolism and Excretion, Absorption, Distribution, Metabolism, and Excretion Study 
A group of pharmacokinetic parameters commonly investigated during preclinical drug development.
National Institutes of Health

Related topics

Related topics

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Clinical Data Interchange Standards Consortium Terminology

Papers overview

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Highly Cited
2013
Highly Cited
2013
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
To ascertain the structure-activity relationship of the core 1,2,4-trioxolane substructure of dispiro ozonides OZ277 and OZ439… 
Review
2006
Review
2006
Integrating molecular design resources within modern drug discovery research: the Roche experience.
Review
2006
Review
2006
High-throughput pKa screening and prediction amenable for ADME profiling
Recent technological advances have made it possible for several new pKa assays to be used in drug screening. In this review, a… 
2006
2006
In silico ADME modelling 2: computational models to predict human serum albumin binding affinity using ant colony systems.
Highly Cited
2005
Highly Cited
2005
Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses.
The clinical progression of new chemical entities to pharmaceuticals remains hindered by the relatively slow pace of technology… 
Highly Cited
2005
Highly Cited
2005
Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated…
Muraglitazar/BMS-298585 (2) has been identified as a non-thiazolidinedione PPAR alpha/gamma dual agonist that shows potent… 
Review
2002
Review
2002
Fragmental Methods in the Design of New Compounds. Applications of The Advanced Algorithm Builder
Fragmental methods (FMs) have great potential in many practical areas related to the design of new lead compounds. Advanced… 
Highly Cited
2002
Highly Cited
2002
Generic method for on-line extraction of drug substances in the presence of biological matrices using turbulent flow chromatography.
The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established… 
Highly Cited
2002
Highly Cited
2002
Pharmacokinetically based mapping device for chemical space navigation.
ChemGPS, the chemical global positioning system, is a tool that combines rules (equivalent to dimensions) and objects (chemical… 
2001
2001
Use of In Vitro Drug Metabolism Data to Evaluate Metabolic Drug‐Drug Interactions in Man: The Need for Quantitative Databases
It has become widely accepted that metabolic drug‐drug interactions can be forecast using in vitro cytochrome P450 (CYP) data… 
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