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ADME Study

Known as: ADME, Absorption, Distribution, Metabolism and Excretion, Absorption, Distribution, Metabolism, and Excretion Study 
A group of pharmacokinetic parameters commonly investigated during preclinical drug development.
National Institutes of Health

Related topics

Related topics

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Clinical Data Interchange Standards Consortium Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Isovaleric acid and avicequinone-C are Chikungunya virus resistance principles in Glycosmis pentaphylla (Retz.) Correa
Background & objectives: Oral administration of tender leaf extract of Glycosmis pentaphylla is traditionally known to prevent… 
Review
2013
Review
2013
Advanced Design and Manufacturing Technology III
This is a collection of selected, peer reviewed papers from the 3rd International Conference on Advanced Design and Manufacturing… 
Review
2006
Review
2006
In vitro ADME medium/high-throughput screening in drug preclinical development.
The study of the ADME features of the huge number of new chemical entities (NCEs) produced mainly by combinatorial chemistry has… 
2005
2005
Simple strategies for reducing sample loads in in vitro metabolic stability high-throughput screening experiments: a comparison between traditional, two-time-point and pooled sample analyses.
Higher-throughput ADME programs in early drug discovery are becoming common throughout the pharmaceutical industry as companies… 
Review
2002
Review
2002
Fragmental Methods in the Design of New Compounds. Applications of The Advanced Algorithm Builder
Fragmental methods (FMs) have great potential in many practical areas related to the design of new lead compounds. Advanced… 
2002
2002
METAPRINT: A Metabolic Fingerprint. Application to Cassette Design for High-Throughput ADME Screening
METAPRINT, a metabolic fingerprint, has been developed by predicting metabolic pathways and corresponding potential metabolites… 
2002
2002
THE PREDICTIVE NATURE OF HIGH-THROUGHPUT TOXICITY SCREENING USING A HUMAN HEPATOCYTE CELL LINE
Drug discovery has become an industrialized process in which vast libraries of compounds are screened for activity against a… 
2000
2000
Diversity Measures for Enhancing ADME Admissibility of Combinatorial Libraries
For general screening libraries, structural diversity descriptors and drug-likeness indicators still do not guarantee the in vivo… 
1999
1999
Use of combinatorial and multiple parallel synthesis methodologies for the development of anti-infective natural products
Abstract 
1999
1999
Early integration of ADME/Tox parameters into the design process of combinatorial libraries
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