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ADME Study

Known as: ADME, Absorption, Distribution, Metabolism and Excretion, Absorption, Distribution, Metabolism, and Excretion Study 
A group of pharmacokinetic parameters commonly investigated during preclinical drug development.
National Institutes of Health

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Clinical Data Interchange Standards Consortium Terminology

Papers overview

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Highly Cited
2013
Highly Cited
2013
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
To ascertain the structure-activity relationship of the core 1,2,4-trioxolane substructure of dispiro ozonides OZ277 and OZ439… 
Highly Cited
2013
Highly Cited
2013
Exploring nature profits: development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids.
2009
2009
Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.
Starting from known piperidine renin inhibitors, a new series of 3,9-diazabicyclo[3.3.1]nonene derivatives was rationally… 
Review
2006
Review
2006
High-throughput pKa screening and prediction amenable for ADME profiling
Recent technological advances have made it possible for several new pKa assays to be used in drug screening. In this review, a… 
Review
2004
Review
2004
Predicting human pharmacokinetics from preclinical data.
Approaches used for the prediction of pharmacokinetics in relevant populations of human patients mostly rely on in vivo data from… 
2003
2003
Prediction of CNS Activity of Compound Libraries Using Substructure Analysis
An in silico ADME/Tox prediction tool based on substructural analysis has been developed. The tool called SUBSTRUCT has been used… 
Highly Cited
2002
Highly Cited
2002
Generic method for on-line extraction of drug substances in the presence of biological matrices using turbulent flow chromatography.
The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established… 
Review
2002
Review
2002
Fragmental Methods in the Design of New Compounds. Applications of The Advanced Algorithm Builder
Fragmental methods (FMs) have great potential in many practical areas related to the design of new lead compounds. Advanced… 
Highly Cited
2002
Highly Cited
2002
Pharmacokinetically based mapping device for chemical space navigation.
ChemGPS, the chemical global positioning system, is a tool that combines rules (equivalent to dimensions) and objects (chemical… 
2001
2001
Use of In Vitro Drug Metabolism Data to Evaluate Metabolic Drug‐Drug Interactions in Man: The Need for Quantitative Databases
It has become widely accepted that metabolic drug‐drug interactions can be forecast using in vitro cytochrome P450 (CYP) data… 
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