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ADME Study

Known as: ADME, Absorption, Distribution, Metabolism and Excretion, Absorption, Distribution, Metabolism, and Excretion Study 
A group of pharmacokinetic parameters commonly investigated during preclinical drug development.
National Institutes of Health

Related topics

Related topics

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Clinical Data Interchange Standards Consortium Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
ABC Transporters in Multi-Drug Resistance and ADME-Tox of Small Molecule Tyrosine Kinase Inhibitors
The past decade has seen tremendous efforts in the research and development of new chemotherapeutic drugs using target-based… 
Highly Cited
2013
Highly Cited
2013
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
To ascertain the structure-activity relationship of the core 1,2,4-trioxolane substructure of dispiro ozonides OZ277 and OZ439… 
Highly Cited
2013
Highly Cited
2013
Exploring nature profits: development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids.
Review
2006
Review
2006
High-throughput pKa screening and prediction amenable for ADME profiling
Recent technological advances have made it possible for several new pKa assays to be used in drug screening. In this review, a… 
Highly Cited
2005
Highly Cited
2005
Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated…
Muraglitazar/BMS-298585 (2) has been identified as a non-thiazolidinedione PPAR alpha/gamma dual agonist that shows potent… 
2004
2004
Automation and robotics in ADME screening.
  • K. Saunders
  • Drug Discovery Today : Technologies
  • 2004
  • Corpus ID: 35308309
Review
2002
Review
2002
Fragmental Methods in the Design of New Compounds. Applications of The Advanced Algorithm Builder
Fragmental methods (FMs) have great potential in many practical areas related to the design of new lead compounds. Advanced… 
Highly Cited
2002
Highly Cited
2002
Pharmacokinetically based mapping device for chemical space navigation.
ChemGPS, the chemical global positioning system, is a tool that combines rules (equivalent to dimensions) and objects (chemical… 
Highly Cited
2002
Highly Cited
2002
Generic method for on-line extraction of drug substances in the presence of biological matrices using turbulent flow chromatography.
The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established… 
2001
2001
Use of In Vitro Drug Metabolism Data to Evaluate Metabolic Drug‐Drug Interactions in Man: The Need for Quantitative Databases
It has become widely accepted that metabolic drug‐drug interactions can be forecast using in vitro cytochrome P450 (CYP) data… 
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