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ADH4 gene

Known as: ADH, CLASS II, ADH-2, ALCOHOL DEHYDROGENASE 4 
This gene plays a role in the oxidation of alcohols.
National Institutes of Health

Related topics

Related topics

5 relations
ADH4 protein, humanEthanol MetabolismOxidation-ReductionQuinone Metabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Hominids adapted to metabolize ethanol long before human-directed fermentation
Significance Many modern human diseases are attributed to incompatibility between our current environment and the environment for… 
Review
2008
Review
2008
Medium- and short-chain dehydrogenase/reductase gene and protein families
Abstract.Retinoic acid (RA), the most active retinoid, is synthesized in two steps from retinol. The first step, oxidation of… 
Highly Cited
2006
Highly Cited
2006
Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism.
BACKGROUND Alcohol dehydrogenase (ADH) is the principal enzyme responsible for ethanol metabolism in mammals. Human ADH… 
Review
2006
Review
2006
REVIEW: The genetics of alcoholism: identifying specific genes through family studies
Alcoholism is a complex disorder with both genetic and environmental risk factors. Studies in humans have begun to elucidate the… 
Highly Cited
2003
Highly Cited
2003
Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract.
ADH1 and ADH4 are the major alcohol dehydrogenases (ADH) in ethanol and retinol oxidation. ADH activity and protein expression… 
Highly Cited
2001
Highly Cited
2001
Mammalian alcohol dehydrogenase - functional and structural implications.
Mammalian alcohol dehydrogenase (ADH) constitutes a complex system with different forms and extensive multiplicity (ADH1-ADH6… 
Highly Cited
2000
Highly Cited
2000
Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all…
Specific combinations of nuclear retinoid receptors acting as ligand-inducible transcription factors mediate the essential role… 
Highly Cited
1999
Highly Cited
1999
Metabolic Deficiencies in Alcohol Dehydrogenase Adh1,Adh3, and Adh4 Null Mutant Mice
Targeting of mouse alcohol dehydrogenase genesAdh1, Adh3, and Adh4 resulted in null mutant mice that all developed and reproduced… 
Highly Cited
1989
Highly Cited
1989
Molecular analysis and nucleotide sequence of the adh1 gene encoding an NADPH-dependent butanol dehydrogenase in the Gram-positive anaerobe Clostridium acetobutylicum.
Highly Cited
1968
Highly Cited
1968
Multiple forms of alcohol dehydrogenase in Saccharomyces cerevisiae. I. Physiological control of ADH-2 and properties of ADH-2 and ADH-4.
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