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ADH-1

A small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and… 
National Institutes of Health

Related topics

Related topics

2 relations
Cadherin-2

Narrower (1)

Exherin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Drug evaluation: ADH-1, an N-cadherin antagonist targeting cancer vascularization.
  • L. Kelland
  • Current opinion in molecular therapeutics (Print)
  • 2007
  • Corpus ID: 28005053
Adherex Technologies Inc, under license from McGill University, is developing ADH-1, an intravenous N-cadherin antagonist that… 
2006
2006
Final clinical and pharmacokinetic (PK) results from a phase 1 study of the novel N-cadherin (N-cad) antagonist, Exherin (ADH-1), in patients with refractory solid tumors stratified according to N…
3016 Background: Malignant transformation and invasiveness correlate with upregulation of N-cad, a cell adhesion molecule… 
2006
2006
An enriched phase I, pharmacokinetic and pharmacodynamic study of the N-cadherin (NCAD) cyclic competitive binder exherin (ADH-1) in patients with solid tumors.
3042 Background: N-cad is a cell adhesion molecule expressed by vascular endothelium and tumor cells of invasive tumors. ADH-1, a… 
2004
2004
Heritable transgene expression pattern imposed onto maize ubiquitin promoter by maize adh-1 matrix attachment regions: tissue and developmental specificity in maize transgenic plants
Matrix attachment regions (MARs) have been used to enhance transgene expression and to reduce transgene expression instability in… 
2002
2002
Expression of genes for alcohol and aldehyde metabolizing enzymes in mouse oocytes and preimplantation embryos.
1994
1994
Isolation and partial characterization of two alcohol dehydrogenase isozymes from the medfly Ceratitis capitata.
1986
1986
Protein engineering of alcohol dehydrogenase--1. Effects of two amino acid changes in the active site of yeast ADH-1.
One of the promises held out by protein engineering is the ability to alter predictably the properties of an enzyme to enable it… 
1981
1981
Mouse alcohol dehydrogenase isozymes: products of closely localized duplicate genes exhibiting divergent kinetic properties.
Electrophoretic variants for the stomach isozyme (ADH-C2) and liver isozyme (ADH-A2) of alcohol dehydrogenase in strains of Mus… 
1977
1977
The genetics of alpha-hydroxyacid oxidase and alcohol dehydrogenase in the mouse: evidence for multiple gene loci and linkage between Hao-2 and Adh-3.
Electrophoretic polymorphisms for stomach alcohol dehydrogenase (ADH-C2) and kidney L-alpha-hydroxyacid oxidase (HAOX-B4) have… 
1971
1971
Developmental expression of alcohol dehydrogenases in maize.
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