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ADAMTS4 Protein

Known as: ADAMTS 4 Protein, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein, Aggrecanase 1 
An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may… 
National Institutes of Health

Related topics

Related topics

8 relations
ADAMTS4 geneIn BloodProcess of secretionantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
The Effect of Protease Inhibitors on the Induction of Osteoarthritis-Related Biomarkers in Bovine Full-Depth Cartilage Explants
Objective The specific degradation of type II collagen and aggrecan by matrix metalloproteinase (MMP)-9, -13 and ADAMTS-4 and -5… 
2011
2011
Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors.
Aggrecanases, particularly aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5), are believed to be key enzymes involved in the… 
Review
2008
Review
2008
Will the real aggrecanase(s) step up: evaluating the criteria that define aggrecanase activity in osteoarthritis.
Loss of aggrecan from articular cartilage is an early and critical event in the pathogenesis of osteoarthritis (OA) and is… 
2007
2007
Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).
ADAMTS-4 (aggrecanase-1) is implicated in the breakdown of articular cartilage and is an attractive target for therapeutic… 
2007
2007
Substrate Conformation Modulates Aggrecanase (ADAMTS-4) Affinity and Sequence Specificity
Protease-substrate interactions are governed by a variety of structural features. Although the substrate sequence specificities… 
2006
2006
Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.
2006
2006
Effects of covalently attached chondroitin sulfate on aggrecan cleavage by ADAMTS-4 and MMP-13.
2005
2005
Oncostatin M in combination with tumour necrosis factor α induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2
Objective: To determine whether oncostatin M (OSM) + tumour necrosis factor α (TNFα) induces aggrecanase activity in chondrocyte… 
Highly Cited
2002
Highly Cited
2002
ADAMTS4 Cleaves at the Aggrecanase Site (Glu373-Ala374) and Secondarily at the Matrix Metalloproteinase Site (Asn341-Phe342) in the Aggrecan Interglobular Domain*
Two major proteolytic cleavages, one at NITEGE373↓A374RGSVI and the other at VDIPEN341↓F342FGVGG, have been shown to occur in… 
2000
2000
Characterization of 5′-flanking region of human aggrecanase-1 (ADAMTS4) gene
Aggrecanase-1, also known as ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4), cleaves at the Glu373… 
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