Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

ADAMTS4 Protein

Known as: ADAMTS 4 Protein, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein, Aggrecanase 1 
An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may… Expand
National Institutes of Health

Related topics

Related topics

8 relations
ADAMTS4 geneIn BloodProcess of secretionantagonists & inhibitors
Expand

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes
Background: Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis… Expand
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons.
Tendinitis remains a catastrophic injury among athletes. Mesenchymal stem cells (MSCs) have recently been investigated for use in… Expand
  • figure 1
  • table 1
  • table 2
  • table 3
  • figure 2
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Leptin plays a catabolic role on articular cartilage
Leptin has been shown to play a crucial role in the regulation of body weight. There is also evidence that this adipokine plays a… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model.
Gene therapy with insulin-like growth factor-1 (IGF-1) increases matrix production and enhances chondrocyte proliferation and… Expand
  • table I
  • table II
  • table IIII
  • figure 5
  • table V
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants.
OBJECTIVE To investigate the effect of glucosamine (GlcN) in a human osteoarthritic explant model on expression of genes involved… Expand
Is this relevant?
Highly Cited
2004
Highly Cited
2004
ADAMTS4 (Aggrecanase-1) Activation on the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated…
C-terminal truncation of ADAMTS-4 from the p68 form to the p53 form is required for activation of its capacity to cleave the… Expand
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Proprotein Convertase Furin Interacts with and Cleaves Pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi Network*
A member of the A disintegrin and metalloproteinase domain with thrombospondin type-1 motifs (ADAMTS-4) protease family can… Expand
Is this relevant?
Highly Cited
2003
Highly Cited
2003
IL-1β induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1β and IL-6 in human tendon cells
Abstract Overuse injuries and trauma in tendon often involve acute or chronic pain and eventual matrix destruction. Anti… Expand
Is this relevant?
Highly Cited
2001
Highly Cited
2001
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
INTRODUCTION Cleavage of aggrecan between residues Glu(373)-Ala(374), which is believed to be a key event in aggrecan destruction… Expand
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE