ADAMTS4 Protein

Known as: ADAMTS 4 Protein, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein, Aggrecanase 1 
An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2017
051019992017

Papers overview

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Highly Cited
2007
Highly Cited
2007
Gene therapy with insulin-like growth factor-1 (IGF-1) increases matrix production and enhances chondrocyte proliferation and… (More)
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2007
2007
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)1, 4, 5, 8, 9 and 15, members of the ADAMTS gene family… (More)
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE Activated synoviocytes play important roles in the progression of human osteoarthritis (OA). Intra-articular injection… (More)
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Highly Cited
2004
Highly Cited
2004
Chondrocytes are influenced by mechanical forces to remodel cartilage extracellular matrix. Previous studies have demonstrated… (More)
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Highly Cited
2004
Highly Cited
2004
C-terminal truncation of ADAMTS-4 from the p68 form to the p53 form is required for activation of its capacity to cleave the Glu… (More)
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Highly Cited
2003
Highly Cited
2003
Overuse injuries and trauma in tendon often involve acute or chronic pain and eventual matrix destruction. Anti-inflammatory… (More)
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Highly Cited
2001
Highly Cited
2001
INTRODUCTION Cleavage of aggrecan between residues Glu(373)-Ala(374), which is believed to be a key event in aggrecan destruction… (More)
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Highly Cited
2001
Highly Cited
2001
ADAMTS4 (aggrecanase-1) is considered to play a key role in the degradation of aggrecan in arthritides. The inhibitory activity… (More)
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Highly Cited
2000
Highly Cited
2000
Brevican is a member of the lectican family of chondroitin sulfate proteoglycans that is predominantly expressed in the central… (More)
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Highly Cited
1999
Highly Cited
1999
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage… (More)
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