FAQ

ADAMTS4 Protein

Known as: ADAMTS 4 Protein, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein, Aggrecanase 1 
An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2017
051019992017

Related topics

Related topics

8 relations
ADAMTS4 geneIn BloodProcess of secretionantagonists & inhibitors
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
ADAMTS4 Protein
physiological aspects
In Blood
chemical synthesis
standards characteristics
ADAMTS4 gene

Papers overview

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Highly Cited
2007
Highly Cited
2007
Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model.
Gene therapy with insulin-like growth factor-1 (IGF-1) increases matrix production and enhances chondrocyte proliferation and… (More)
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2007
2007
Expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic cartilage.
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)1, 4, 5, 8, 9 and 15, members of the ADAMTS gene family… (More)
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Highly Cited
2006
Highly Cited
2006
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
OBJECTIVE Activated synoviocytes play important roles in the progression of human osteoarthritis (OA). Intra-articular injection… (More)
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Highly Cited
2004
Highly Cited
2004
Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP.
Chondrocytes are influenced by mechanical forces to remodel cartilage extracellular matrix. Previous studies have demonstrated… (More)
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Highly Cited
2004
Highly Cited
2004
ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated…
C-terminal truncation of ADAMTS-4 from the p68 form to the p53 form is required for activation of its capacity to cleave the Glu… (More)
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Highly Cited
2003
Highly Cited
2003
IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells.
Overuse injuries and trauma in tendon often involve acute or chronic pain and eventual matrix destruction. Anti-inflammatory… (More)
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Highly Cited
2001
Highly Cited
2001
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
INTRODUCTION Cleavage of aggrecan between residues Glu(373)-Ala(374), which is believed to be a key event in aggrecan destruction… (More)
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Highly Cited
2001
Highly Cited
2001
Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4).
ADAMTS4 (aggrecanase-1) is considered to play a key role in the degradation of aggrecan in arthritides. The inhibitory activity… (More)
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Highly Cited
2000
Highly Cited
2000
Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.
Brevican is a member of the lectican family of chondroitin sulfate proteoglycans that is predominantly expressed in the central… (More)
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Highly Cited
1999
Highly Cited
1999
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage… (More)
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