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ADAMTS4 Protein
Known as:
ADAMTS 4 Protein
, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein
, Aggrecanase 1
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An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may…
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National Institutes of Health
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8 relations
ADAMTS4 gene
In Blood
Process of secretion
antagonists & inhibitors
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction
Siyoung Yang
,
Jonghwan Kim
,
+5 authors
J. Chun
Nature Network Boston
2010
Corpus ID: 23605787
Osteoarthritic cartilage destruction is caused by an imbalance between anabolic and catabolic factors. Here, we show that hypoxia…
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Highly Cited
2009
Highly Cited
2009
Mesenchymal stem cells and insulin‐like growth factor‐I gene‐enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons
L. Schnabel
,
M. Lynch
,
M. V. D. van der Meulen
,
A. Yeager
,
M. Kornatowski
,
A. Nixon
Journal of Orthopaedic Research
2009
Corpus ID: 9342022
Tendinitis remains a catastrophic injury among athletes. Mesenchymal stem cells (MSCs) have recently been investigated for use in…
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Highly Cited
2006
Highly Cited
2006
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
C.‐T. Wang
,
Y.‐T. Lin
,
B. Chiang
,
Y-H. Lin
,
S. Hou
Osteoarthritis and Cartilage
2006
Corpus ID: 5777062
Highly Cited
2004
Highly Cited
2004
Mechanical Compression of Cartilage Explants Induces Multiple Time-dependent Gene Expression Patterns and Involves Intracellular Calcium and Cyclic AMP*
J. Fitzgerald
,
M. Jin
,
D. Dean
,
D. Wood
,
M. Zheng
,
A. Grodzinsky
Journal of Biological Chemistry
2004
Corpus ID: 24747139
Chondrocytes are influenced by mechanical forces to remodel cartilage extracellular matrix. Previous studies have demonstrated…
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Highly Cited
2003
Highly Cited
2003
IL‐1β induces COX2, MMP‐1, ‐3 and ‐13, ADAMTS‐4, IL‐1β and IL‐6 in human tendon cells
M. Tsuzaki
,
G. Guyton
,
+6 authors
A. Banes
2003
Corpus ID: 71989036
Highly Cited
2002
Highly Cited
2002
Matrix Metalloproteinases Cleave Connective Tissue Growth Factor and Reactivate Angiogenic Activity of Vascular Endothelial Growth Factor 165*
G. Hashimoto
,
I. Inoki
,
Y. Fujii
,
T. Aoki
,
E. Ikeda
,
Y. Okada
Journal of Biological Chemistry
2002
Corpus ID: 25163818
Vascular endothelial growth factor (VEGF), a potent angiogenic mitogen, plays a crucial role in angiogenesis under various…
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Highly Cited
2001
Highly Cited
2001
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
M. Tortorella
,
A. Malfait
,
C. Deccico
,
E. Arner
Osteoarthritis and Cartilage
2001
Corpus ID: 45975962
INTRODUCTION Cleavage of aggrecan between residues Glu(373)-Ala(374), which is believed to be a key event in aggrecan destruction…
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Highly Cited
2000
Highly Cited
2000
The Thrombospondin Motif of Aggrecanase-1 (ADAMTS-4) Is Critical for Aggrecan Substrate Recognition and Cleavage*
M. Tortorella
,
M. Pratta
,
+4 authors
E. Arner
Journal of Biological Chemistry
2000
Corpus ID: 17170531
Aggrecanase-1 (ADAMTS-4) is a member of thea disintegrin andmetalloprotease withthrombospondin motifs (ADAMTS) protein family…
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Highly Cited
1999
Highly Cited
1999
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
M. Tortorella
,
T. Burn
,
+25 authors
E. Arner
Science
1999
Corpus ID: 20853163
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage…
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Highly Cited
1999
Highly Cited
1999
Cloning and Characterization of ADAMTS11, an Aggrecanase from the ADAMTS Family*
I. Abbaszade
,
Rui-Qin Liu
,
+24 authors
T. Burn
Journal of Biological Chemistry
1999
Corpus ID: 21516260
Aggrecan is responsible for the mechanical properties of cartilage. One of the earliest changes observed in arthritis is the…
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