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ADAMTS4 Protein

Known as: ADAMTS 4 Protein, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein, Aggrecanase 1 
An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Background: Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis… Expand
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Highly Cited
2009
Highly Cited
2009
Tendinitis remains a catastrophic injury among athletes. Mesenchymal stem cells (MSCs) have recently been investigated for use in… Expand
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Highly Cited
2009
Highly Cited
2009
Leptin has been shown to play a crucial role in the regulation of body weight. There is also evidence that this adipokine plays a… Expand
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Highly Cited
2007
Highly Cited
2007
Gene therapy with insulin-like growth factor-1 (IGF-1) increases matrix production and enhances chondrocyte proliferation and… Expand
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE To investigate the effect of glucosamine (GlcN) in a human osteoarthritic explant model on expression of genes involved… Expand
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Highly Cited
2004
Highly Cited
2004
C-terminal truncation of ADAMTS-4 from the p68 form to the p53 form is required for activation of its capacity to cleave the… Expand
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Highly Cited
2004
Highly Cited
2004
A member of the A disintegrin and metalloproteinase domain with thrombospondin type-1 motifs (ADAMTS-4) protease family can… Expand
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Highly Cited
2003
Highly Cited
2003
Abstract Overuse injuries and trauma in tendon often involve acute or chronic pain and eventual matrix destruction. Anti… Expand
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Highly Cited
2001
Highly Cited
2001
INTRODUCTION Cleavage of aggrecan between residues Glu(373)-Ala(374), which is believed to be a key event in aggrecan destruction… Expand
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Highly Cited
1999
Highly Cited
1999
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage… Expand
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