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ADAMTS4 Protein

Known as: ADAMTS 4 Protein, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein, Aggrecanase 1 
An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may… 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Osteoarthritic cartilage destruction is caused by an imbalance between anabolic and catabolic factors. Here, we show that hypoxia… 
Highly Cited
2009
Highly Cited
2009
Tendinitis remains a catastrophic injury among athletes. Mesenchymal stem cells (MSCs) have recently been investigated for use in… 
Highly Cited
2004
Highly Cited
2004
Chondrocytes are influenced by mechanical forces to remodel cartilage extracellular matrix. Previous studies have demonstrated… 
Highly Cited
2002
Highly Cited
2002
Vascular endothelial growth factor (VEGF), a potent angiogenic mitogen, plays a crucial role in angiogenesis under various… 
Highly Cited
2001
Highly Cited
2001
INTRODUCTION Cleavage of aggrecan between residues Glu(373)-Ala(374), which is believed to be a key event in aggrecan destruction… 
Highly Cited
2000
Highly Cited
2000
Aggrecanase-1 (ADAMTS-4) is a member of thea disintegrin andmetalloprotease withthrombospondin motifs (ADAMTS) protein family… 
Highly Cited
1999
Highly Cited
1999
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage… 
Highly Cited
1999
Highly Cited
1999
Aggrecan is responsible for the mechanical properties of cartilage. One of the earliest changes observed in arthritis is the…