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ADAMTS4 Protein

Known as: ADAMTS 4 Protein, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein, Aggrecanase 1 
An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most common form of arthritis. Clinical… Expand
Highly Cited
2010
Highly Cited
2010
Osteoarthritic cartilage destruction is caused by an imbalance between anabolic and catabolic factors. Here, we show that hypoxia… Expand
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Highly Cited
2009
Highly Cited
2009
Tendinitis remains a catastrophic injury among athletes. Mesenchymal stem cells (MSCs) have recently been investigated for use in… Expand
Highly Cited
2009
Highly Cited
2009
Background: Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis… Expand
Highly Cited
2006
Highly Cited
2006
OBJECTIVE Activated synoviocytes play important roles in the progression of human osteoarthritis (OA). Intra-articular injection… Expand
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Highly Cited
2004
Highly Cited
2004
Chondrocytes are influenced by mechanical forces to remodel cartilage extracellular matrix. Previous studies have demonstrated… Expand
Highly Cited
2004
Highly Cited
2004
C-terminal truncation of ADAMTS-4 from the p68 form to the p53 form is required for activation of its capacity to cleave the… Expand
Highly Cited
2002
Highly Cited
2002
Vascular endothelial growth factor (VEGF), a potent angiogenic mitogen, plays a crucial role in angiogenesis under various… Expand
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Highly Cited
2001
Highly Cited
2001
INTRODUCTION Cleavage of aggrecan between residues Glu(373)-Ala(374), which is believed to be a key event in aggrecan destruction… Expand
Highly Cited
1999
Highly Cited
1999
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage… Expand