Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

ADAMTS4 Protein

Known as: ADAMTS 4 Protein, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein, Aggrecanase 1 
An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may… Expand
National Institutes of Health

Related topics

Related topics

8 relations
ADAMTS4 geneIn BloodProcess of secretionantagonists & inhibitors
Expand

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Pro-inflammatory cytokines: The link between obesity and osteoarthritis.
Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most common form of arthritis. Clinical… Expand
Highly Cited
2010
Highly Cited
2010
Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction
Osteoarthritic cartilage destruction is caused by an imbalance between anabolic and catabolic factors. Here, we show that hypoxia… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2009
Highly Cited
2009
Mesenchymal stem cells and insulin‐like growth factor‐I gene‐enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons
Tendinitis remains a catastrophic injury among athletes. Mesenchymal stem cells (MSCs) have recently been investigated for use in… Expand
Highly Cited
2009
Highly Cited
2009
Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes
Background: Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis… Expand
Highly Cited
2006
Highly Cited
2006
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
OBJECTIVE Activated synoviocytes play important roles in the progression of human osteoarthritis (OA). Intra-articular injection… Expand
  • figure 1
  • table I
  • figure 2
  • figure 3
  • figure 4
Highly Cited
2004
Highly Cited
2004
Mechanical Compression of Cartilage Explants Induces Multiple Time-dependent Gene Expression Patterns and Involves Intracellular Calcium and Cyclic AMP*
Chondrocytes are influenced by mechanical forces to remodel cartilage extracellular matrix. Previous studies have demonstrated… Expand
Highly Cited
2004
Highly Cited
2004
ADAMTS4 (Aggrecanase-1) Activation on the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated…
C-terminal truncation of ADAMTS-4 from the p68 form to the p53 form is required for activation of its capacity to cleave the… Expand
Highly Cited
2002
Highly Cited
2002
Matrix Metalloproteinases Cleave Connective Tissue Growth Factor and Reactivate Angiogenic Activity of Vascular Endothelial Growth Factor 165*
Vascular endothelial growth factor (VEGF), a potent angiogenic mitogen, plays a crucial role in angiogenesis under various… Expand
  • figure 1
  • figure 2
  • figure 3
  • table I
  • figure 4
Highly Cited
2001
Highly Cited
2001
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
INTRODUCTION Cleavage of aggrecan between residues Glu(373)-Ala(374), which is believed to be a key event in aggrecan destruction… Expand
Highly Cited
1999
Highly Cited
1999
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE