A. Fosang | Semantic Scholar

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice

D. Stickens, Danielle J. Behonick, Z. Werb
Biology, Engineering
Development
1 December 2004

The hypothesis that proper ECM remodeling is the dominant rate-limiting process for programmed cell death, angiogenesis and osteoblast recruitment during normal skeletal morphogenesis is supported.

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

H. Stanton, F. Rogerson, A. Fosang
Biology
Nature
31 March 2005

The data suggest that ADAMts5 may be a suitable target for the development of new drugs designed to inhibit cartilage destruction in arthritis, although further work will be required to determine whether ADAMTS5 is also the major aggrecanase in human arthritis.

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Proteoglycans: many forms and many functions

T. Hardingham, A. Fosang
Biology
FASEB journal : official publication of the…
1 February 1992

The control of glycosaminoglycan structure is not well understood, but it does appear to be used to change the properties of proteoglycans to suit different biological needs.

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Degradation of cartilage aggrecan by collagenase‐3 (MMP‐13)

A. Fosang, K. Last, V. Knäuper, G. Murphy, P. Neame
Biology
FEBS letters
12 February 1996

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Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

C. Little, A. Barai, E. Thompson
Medicine, Biology
Arthritis and rheumatism
1 December 2009

OBJECTIVE To investigate the role of matrix metalloproteinase 13 (MMP-13; collagenase 3) in osteoarthritis (OA). METHODS OA was surgically induced in the knees of MMP-13-knockout mice and wild-type…

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The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.

A. Fosang, P. Neame, K. Last, T. Hardingham, G. Murphy, J. Hamilton
Biology, Chemistry
The Journal of biological chemistry
25 September 1992

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Hyaluronan synthesis and degradation in cartilage and bone

E. Bastow, S. Byers, S. Golub, C. Clarkin, A. Pitsillides, A. Fosang
Biology, Engineering
Cellular and Molecular Life Sciences
1 February 2008

The role and regulation of HA synthesis and degradation in cartilage, bone and skeletal development is discussed and the functions of HA depend on its intrinsic properties, which in turn rely on the degree of polymerisation by HA synthases, depolymerisation by hyaluronidases, and interactions with HA-binding proteins.

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Proteoglycan degradation by the ADAMTS family of proteinases.

H. Stanton, J. Melrose, C. Little, A. Fosang
Biology
Biochimica et biophysica acta
1 December 2011

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Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair.

C. Little, Clare T. Meeker, A. Fosang
Biology, Medicine
The Journal of clinical investigation
1 June 2007

Blocking cleavage in the IGD not only diminished aggrecan loss and cartilage erosion in surgically induced osteoarthritis and a model of inflammatory arthritis, but appeared to stimulate cartilage repair following acute inflammation.

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Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.

C. Hughes, B. Caterson, A. Fosang, P. Roughley, J. Mort
Biology
The Biochemical journal
1 February 1995

Results demonstrate that 'aggrecanase' activity is not a constitutive event in all cartilage culture systems and suggest that proteolytic agents other than 'aggREcanase" are involved in aggrecan catabolism in normal turnover compared with pathological conditions.

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