ADAMTS1 protein, human

Known as: METH-1 protein,. human, ADAMTS1, ADAMTS-1 protein, human 
A disintegrin and metalloproteinase with thrombospondin motifs 1 (967 aa, ~105 kDa) is encoded by the human ADAMTS1 gene. This protein plays a role… (More)
National Institutes of Health

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Broader (1)

ADAMTS1 Protein
ADAMTS1 geneAngiogenesis InhibitionDisintegrin DomainEnzyme Gene
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Papers overview

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Highly Cited
2012
Highly Cited
2012
Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury.
Kidney pericytes are progenitors of scar-forming interstitial myofibroblasts that appear after injury. The function of kidney… (More)
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2012
2012
Upregulation of a disintegrin and metalloproteinase with thrombospondin motifs-7 by miR-29 repression mediates vascular smooth muscle calcification.
OBJECTIVE Vascular calcification significantly increases cardiovascular morbidity and mortality. We recently reported that the… (More)
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2009
2009
ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells.
ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) is a member of the matrix metalloproteinase family. We… (More)
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Highly Cited
2008
Highly Cited
2008
Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.
Developing myocardial cells respond to signals from the endocardial layer to form a network of trabeculae that characterize the… (More)
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Highly Cited
2003
Highly Cited
2003
ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165.
ADAMTS1 is a metalloprotease previously shown to inhibit angiogenesis in a variety of in vitro and in vivo assays. In the present… (More)
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2000
2000
Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms.
METH-1/ADAMTS1 is a member of a newly described family of genes that contain metalloprotease, disintegrin, and thrombospondin… (More)
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Highly Cited
2000
Highly Cited
2000
Ovulation: a multi-gene, multi-step process
The luteinizing hormone (LH) surge initiates a cascade of proteolytic events that control ovulation. One of the genes induced by… (More)
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Highly Cited
1999
Highly Cited
1999
METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity.
We have studied two related proteins that contain a repeated amino acid motif homologous to the anti-angiogenic type 1 repeats of… (More)
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1999
1999
ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix.
Cellular disintegrin and metalloproteinases (ADAMs) are a family of genes with a sequence similar to the snake venom… (More)
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Highly Cited
1997
Highly Cited
1997
Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.
A cellular disintegrin and metalloproteinase (ADAM) is a new family of genes with structural homology to the snake venom… (More)
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