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ACTN1 protein, human

Known as: actinin, alpha 1 protein, human, Non-Muscle Alpha-Actinin-1, Actinin 1 Smooth Muscle 
Alpha-actinin-1 (892 aa, ~103 kDa) is encoded by the human ACTN1 gene. This protein plays a role in F-actin crosslinking.
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Actin stress fibers (SFs) enable cells to sense and respond to mechanical stimuli and affect adhesion, motility and apoptosis. We… Expand
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Highly Cited
2008
Highly Cited
2008
Actin assembly at the cell front drives membrane protrusion and initiates the cell migration cycle. Microtubules (MTs) extend… Expand
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Highly Cited
2008
Highly Cited
2008
T lymphocytes use LFA‐1 to migrate into lymph nodes and inflammatory sites. To investigate the mechanisms regulating this… Expand
Highly Cited
2007
Highly Cited
2007
Force generated in contractile actin filament bundles (stress fibers-SFs) is transmitted to the extracellular matrix (ECM) via… Expand
Highly Cited
2007
Highly Cited
2007
Physical forces including pressure, strain, and shear can be converted into intracellular signals that regulate diverse aspects… Expand
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Highly Cited
2003
Highly Cited
2003
Dominantly inherited mutations in ACTN4, which encodes alpha-actinin-4, cause a form of human focal and segmental… Expand
Highly Cited
2002
Highly Cited
2002
To gain insight into the dynamic properties of focal contacts, we induced expression of green fluorescent protein‐tagged β3… Expand
Highly Cited
2000
Highly Cited
2000
The PDZ-LIM family of proteins (Enigma/LMP-1, ENH, ZASP/Cypher, RIL, ALP, and CLP-36) has been suggested to act as adapters that… Expand
Highly Cited
2000
Highly Cited
2000
A 38-kd protein that associates with F-actin structures in activated platelets and endothelial cells was purified, cloned, and… Expand
Highly Cited
1999
Highly Cited
1999
Subcellular targeting and the activity of facilitative glucose transporters are likely to be regulated by interactions with… Expand
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