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ABT751

Known as: ABT-751 
An orally bioavailable antimitotic sulfonamide. ABT- 751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of… 
National Institutes of Health

Related topics

Related topics

4 relations
E 7010Microtubule ProcessNCIt Antineoplastic Agent Terminology

Broader (1)

Sulfonamides

Papers overview

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2016
2016
Microtubule targeting agents: mechanisms of action and classification Microtubules are dynamic tubular polymers of α- and β-tubulin which provide structural integrity, promote migration, transport of…
Microtubules are dynamic tubular polymers of αand β-tubulin which provide structural integrity, promote migration, transport of… 
2008
2008
Activity of fenretinide/Lym-X-Sorb oral powder combined with the oral microtubule inhibitor ABT-751 against multidrug-resistant neuroblastoma xenografts
10031 Background: ABT-751, a colchicine binding-site microtubule inhibitor, and fenretinide [N-(4 hydroxyphenyl) retinamide, 4… 
2007
2007
The pharmacokinetics (PK) and pharmacodynamics (PD) of ABT-751 in children with recurrent neuroblastoma or other solid tumors
9557 Background: ABT-751 is an orally administered agent that binds to the colchicine site on β-tubulin and blocks microtubule… 
2006
2006
The Pharmacokinetics and Safety of ABT-751 , a Novel , Orally Bioavailable SulfonamideAntimitotic Agent : Results of a Phase 1 Study
Purpose: Microtubules play a critical role in many cellular functions, including cell division and mitosis. ABT-751is a novel… 
2004
2004
Continuous administration regimen by Abt-751
Anticancer N-- coupling (2 ((4-hydroxyphenyl) amino) pyrid-3-yl) -4 containing methoxybenzenesulfonamide (ABT-751) composition…