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ABT 431

Known as: ABT-431, DAS-431 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
RationaleD1-Like agonists are self-administered by drug-naive animals, whereas D2-like agonists reinstate cocaine-seeking… 
Highly Cited
2004
Highly Cited
2004
A natural consequence of aging is a loss of dopamine function and associated deficits in working memory in both human and… 
2004
2004
AbstractPurpose. ABT-431 is a chemically stable, poorly soluble prodrug that rapidly converts in vivo to A-86929, a selective… 
Highly Cited
2001
Highly Cited
2001
BACKGROUND Dyskinesias are a frequent adverse effect of long-term levodopa therapy. The relative contribution of dopamine D(1… 
Review
2001
Review
2001
Adrogolide (ABT-431; DAS-431) is a chemically stable prodrug that is converted rapidly (<1 min) in plasma to A-86929, a full… 
2001
2001
Methods: We studied ABT-431, the prodrug of a fully selective D1 agonist, in 20 subjects with advanced Parkinson disease and a… 
Highly Cited
2000
Highly Cited
2000
Abstract: Selective D1 dopamine agonists represent a potential pharmacotherapy for the treatment of cocaine addiction. Here we… 
Highly Cited
1999
Highly Cited
1999
Studies in animal models show a selective D1 receptor agonist with full functional efficacy compared with dopamine to have… 
Highly Cited
1999
Highly Cited
1999
Rationale: Data in laboratory animals suggest that D1 receptor agonists may have potential utility for the treatment of cocaine… 
Highly Cited
1996
Highly Cited
1996
(-)-Trans 9,10-hydroxy-2-propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5- azacyclopent-1-ena[c]phenanthrene hydrochloride (A-86929) is a…