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ABT-089

Known as: A-87089.0, ABT 089, ABYT 089 
National Institutes of Health

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1 relation

Broader (1)

pozanicline

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice
Nicotine withdrawal produces cognitive deficits that can predict relapse. Amelioration of these cognitive deficits emerges as a… 
Review
2014
Review
2014
Role for the nicotinic cholinergic system in movement disorders; therapeutic implications.
2014
2014
Administration of the nicotinic acetylcholine receptor agonists ABT-089 and ABT-107 attenuates the reinstatement of nicotine-seeking behavior in rats
2012
2012
A randomized pilot study of the efficacy and safety of ABT-089, a novel α4β2 neuronal nicotinic receptor agonist, in adults with attention-deficit/hyperactivity disorder.
OBJECTIVE ABT-089, an α4β2 neuronal nicotinic receptor partial agonist (generic name pozanicline), has demonstrated efficacy in… 
2011
2011
Pharmacokinetic Modeling and [123I]5-IA-85380 Single Photon Emission Computed Tomography Imaging in Baboons: Optimization of Dosing Regimen for ABT-089
Neuronal acetylcholine nicotinic receptors (nAChRs) are targets for the development of novel treatments of brain diseases… 
2011
2011
Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent α4β2 nicotinic acetylcholine receptor ligands.
A series of diazabicyclo[3.3.0]octane substituted pyridines and pyrazines was synthesized and characterized at the α4β2 neuronal… 
2009
2009
Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain.
2005
2005
Coupling of human nicotinic acetylcholine receptors alpha 7 to calcium channels in GH3 cells.
The neuronal nicotinic acetylcholine receptor alpha7 (nAChR alpha7) may be involved in cognitive deficits in Schizophrenia and… 
1999
1999
Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant.
In the human alpha7 nicotinic receptor, valine-274 in the pore-lining transmembrane-2 region was mutated to threonine to produce… 
1998
1998
Alzheimer's disease therapy - an update.
The 5th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy focused on new therapeutic approaches for the… 
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