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ABT-089

Known as: A-87089.0, ABT 089, ABYT 089 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

pozanicline

Papers overview

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Highly Cited
2013
Highly Cited
2013
Cholinergic Control over Attention in Rats Prone to Attribute Incentive Salience to Reward Cues
Some rats [sign-trackers (STs)] are especially prone to attribute incentive salience to reward cues, relative to others [goal… Expand
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2011
2011
Efficacy and safety of the novel α4β2 neuronal nicotinic receptor partial agonist ABT-089 in adults with attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled…
Rationaleα4β2 Neuronal nicotinic receptors (NNRs) are implicated in the pathophysiology of attention-deficit/hyperactivity… Expand
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Highly Cited
2008
Highly Cited
2008
Glutamatergic Contributions to Nicotinic Acetylcholine Receptor Agonist-Evoked Cholinergic Transients in the Prefrontal Cortex
Because modulation of cortical cholinergic neurotransmission has been hypothesized to represent a necessary mechanism mediating… Expand
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Review
2007
Review
2007
Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: focus on cognition.
Attention deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurobehavioral disorder in children and… Expand
Highly Cited
2006
Highly Cited
2006
ABT-089, A Neuronal Nicotinic Receptor Partial Agonist, for the Treatment of Attention-Deficit/Hyperactivity Disorder in Adults: Results of a Pilot Study
BACKGROUND This pilot study was designed to evaluate ABT-089, a neuronal nicotinic receptor partial agonist, as treatment for… Expand
Review
2004
Review
2004
ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders.
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride salt] is a selective neuronal nicotinic receptor (NNR… Expand
Highly Cited
1998
Highly Cited
1998
Central nicotinic receptor agonists ABT-418, ABT-089, and (–)-nicotine reduce distractibility in adult monkeys
Abstract Increased distractibility is associated with both Alzheimer’s disease and attention deficit disorder. The present study… Expand
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Highly Cited
1997
Highly Cited
1997
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys.
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride], a novel ligand at neuronal nicotinic acetylcholine… Expand
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1997
1997
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing…
2-Methyl-3-(2(S)-pyrrolidinylmethoxy)pyridine, ABT-089 (S-4), a member of the 3-pyridyl ether class of nicotinic acetylcholine… Expand
Highly Cited
1997
Highly Cited
1997
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties.
Accumulating preclinical and clinical evidence data suggests that compounds that selectively activate neuronal nicotinic… Expand
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