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ABT-089

Known as: A-87089.0, ABT 089, ABYT 089 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

pozanicline

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Role for the nicotinic cholinergic system in movement disorders; therapeutic implications.
2014
2014
ABT‐089 and ABT‐894 reduce levodopa‐induced dyskinesias in a monkey model of Parkinson's disease
Levodopa‐induced dyskinesias (LIDs) are a serious complication of levodopa therapy for Parkinson's disease for which there is… 
2009
2009
Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination.
Highly Cited
2008
Highly Cited
2008
Glutamatergic Contributions to Nicotinic Acetylcholine Receptor Agonist-Evoked Cholinergic Transients in the Prefrontal Cortex
Because modulation of cortical cholinergic neurotransmission has been hypothesized to represent a necessary mechanism mediating… 
Review
2007
Review
2007
Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: focus on cognition.
Review
2004
Review
2004
ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders.
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride salt] is a selective neuronal nicotinic receptor (NNR… 
Highly Cited
1998
Highly Cited
1998
Central nicotinic receptor agonists ABT-418, ABT-089, and (–)-nicotine reduce distractibility in adult monkeys
Abstract Increased distractibility is associated with both Alzheimer’s disease and attention deficit disorder. The present study… 
Highly Cited
1998
Highly Cited
1998
Activation and inhibition of the human α7 nicotinic acetylcholine receptor by agonists
Highly Cited
1997
Highly Cited
1997
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys.
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride], a novel ligand at neuronal nicotinic acetylcholine… 
Highly Cited
1997
Highly Cited
1997
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties.
Accumulating preclinical and clinical evidence data suggests that compounds that selectively activate neuronal nicotinic… 
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