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Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
Bipolar disorder (BD) has been associated with abnormalities of brain structure. Expand
Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls.
CONTEXT An instructive paradigm for investigating the relationship between brain serotonin function and major depressive disorder (MDD) is the response to tryptophan depletion (TD) induced by oralExpand
Mood-congruent bias in affective go/no-go performance of unmedicated patients with major depressive disorder.
OBJECTIVE Neuropsychological studies of major depressive disorder have described attentional biases for affectively laden stimuli, but these reports were based on measures obtained from medicatedExpand
Reduced Serotonin Type 1A Receptor Binding in Panic Disorder
Recent animal models suggest that disturbances in serotonin type-1A receptor (5-HT1AR) function may contribute to chronic anxiety, although it is not clear at all whether such models constituteExpand
A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression.
OBJECTIVE Neuropsychological studies of bipolar disorder reveal deficits in a variety of domains, including affective processing, memory, and sustained attention. These findings are difficult toExpand
Reduced posterior hippocampal volume in posttraumatic stress disorder.
OBJECTIVE Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certainExpand
Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: The impact of medication
MRI-based reports of both abnormally increased and decreased amygdala volume in bipolar disorder (BD) have surfaced in the literature. Expand
A Randomized Trial to Assess the Efficacy and Safety of ABT-126, a Selective α7 Nicotinic Acetylcholine Receptor Agonist, in the Treatment of Cognitive Impairment in Schizophrenia.
OBJECTIVE The authors sought to evaluate the efficacy and safety of ABT-126, a selective α7 nicotinic receptor partial agonist, in stable patients with schizophrenia. METHOD A 12-week,Expand
Heart rate variability during motor and cognitive tasks in females with major depressive disorder
Research indicates that major depressive disorder (MDD) is associated with alterations in autonomic control, particularly cardiac control as measured by heart rate variability (HRV). In thisExpand
A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of α4β2 Agonist ABT-894 in Adults with ADHD
Dysregulation of the neuronal nicotinic acetylcholine receptor (NNR) system has been implicated in attention-deficit/hyperactivity disorder (ADHD), and nicotinic agonists improve attention acrossExpand