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ABHD12 gene

Known as: ABHD12A, abhydrolase domain containing 12, dJ965G21.2 
This gene plays a role in endocannabinoid metabolism.
National Institutes of Health

Related topics

Related topics

4 relations
ABHD12 protein, humanDrug Metabolism InductionHydrolysisLipid Metabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells.
Ferroptosis is a type of cell death caused by the pathogenic accumulation of lipid hydroperoxides. Pharmacological mechanisms to… 
2019
2019
Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12).
ABHD12 is a membrane-bound hydrolytic enzyme that acts on the lysophosphatidylserine (lyso-PS) and lysophosphatidylinositol (lyso… 
2015
2015
Novel ABHD12 Mutations in PHARC Patients
Objective: This study examines ABHD12 mutation analysis in 2 PHARC patients, originally thought to be Usher syndrome. Methods… 
Highly Cited
2014
Highly Cited
2014
Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay
Lysophosphatidylserines (lyso-PSs) are a class of signaling lipids that regulate immunological and neurological processes. The… 
2014
2014
Discovery of Triterpenoids as Reversible Inhibitors of α/β-hydrolase Domain Containing 12 (ABHD12)
Background α/β-hydrolase domain containing (ABHD)12 is a recently discovered serine hydrolase that acts in vivo as a… 
2014
2014
Exome sequencing extends the phenotypic spectrum for ABHD12 mutations: from syndromic to nonsyndromic retinal degeneration.
2013
2013
Two Novel Mutations in ABHD12: Expansion of the Mutation Spectrum in PHARC and Assessment of Their Functional Effects
PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataracts) is a recently described autosomal‐recessive… 
Highly Cited
2012
Highly Cited
2012
Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)[S]
In the central nervous system, three enzymes belonging to the serine hydrolase family are thought to regulate the life time of… 
Highly Cited
2012
Highly Cited
2012
Targeted next-generation sequencing identifies a homozygous nonsense mutation in ABHD12, the gene underlying PHARC, in a family clinically diagnosed with Usher syndrome type 3
BackgroundUsher syndrome (USH) is an autosomal recessive genetically heterogeneous disorder with congenital sensorineural hearing… 
Highly Cited
2011
Highly Cited
2011
COX‐2 and fatty acid amide hydrolase can regulate the time course of depolarization‐induced suppression of excitation
BACKGROUND AND PURPOSE Depolarization‐induced suppression of inhibition (DSI) and excitation (DSE) are two forms of cannabinoid… 
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