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Depolarization‐induced suppression of excitation in murine autaptic hippocampal neurones
Depolarization‐induced suppression of excitation and inhibition (DSE and DSI) appear to be important forms of short‐term retrograde neuronal plasticity involving endocannabinoids (eCB) and theExpand
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JWH018, a common constituent of ‘Spice’ herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist
Background and purpose:  ‘Spice’ is an herbal blend primarily marketed in Europe as a mild hallucinogen with prominent cannabis‐like effects and as a legal alternative to cannabis. However, a recentExpand
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Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
BackgroundG protein coupled receptors (GPCRs) are one of the most widely studied gene superfamilies. Thousands of GPCR research studies have utilized heterologous expression systems such as humanExpand
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Cannabinoid CB1 receptors and ligands in vertebrate retina: localization and function of an endogenous signaling system.
CB1, a cannabinoid receptor enriched in neuronal tissue, was found in high concentration in retinas of rhesus monkey, mouse, rat, chick, goldfish, and tiger salamander by using a subtype-specificExpand
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Localization of cannabinoid CB1 receptors in the human anterior eye and retina.
PURPOSE To determine the presence and distribution of CB1 cannabinoid receptors within the human eye. METHODS A subtype-specific affinity-purified polyclonal antibody to the cannabinoid CB1Expand
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Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection.
Focal cerebral ischemia and traumatic brain injury induce an escalating amount of cell death because of harmful mediators diffusing from the original lesion site. Evidence suggests that healthy cellsExpand
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Functional Selectivity in CB2 Cannabinoid Receptor Signaling and Regulation: Implications for the Therapeutic Potential of CB2 Ligands
Receptor internalization increases the flexibility and scope of G protein-coupled receptor (GPCR) signaling. CB1 and CB2 cannabinoid receptors undergo internalization after sustained exposure toExpand
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Architecture of cannabinoid signaling in mouse retina
Cannabinoid receptors and their ligands constitute an endogenous signaling system that is found throughout the body, including the eye. This system can be activated by Δ9‐tetrahydrocannabinol, aExpand
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Parsing the players: 2‐arachidonoylglycerol synthesis and degradation in the CNS
The endogenous cannabinoid signalling system, composed of endogenous cannabinoids, cannabinoid receptors and the enzymes that synthesize and degrade the endogenous cannabinoids, is much more complexExpand
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Monoacylglycerol Lipase Limits the Duration of Endocannabinoid-Mediated Depolarization-Induced Suppression of Excitation in Autaptic Hippocampal Neurons
Depolarization-induced suppression of excitation (DSE) is a major form of cannabinoid-mediated short-term retrograde neuronal plasticity and is found in numerous brain regions. Autaptically culturedExpand
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