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International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
It is considered premature to rename cannabinoid receptors after an endogenous agonist as is recommended by the International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification, because pharmacological evidence for the existence of additional types of cannabinoid receptor is emerging and other kinds of supporting evidence are still lacking.
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
This review summarizes current data indicating the extent to which cannabinoid receptor ligands undergo orthosteric or allosteric interactions with non- CB1, non-CB2 established GPCRs, deorphanized receptors such as GPR55, ligand-gated ion channels, transient receptor potential (TRP) channels, and other ion channels or peroxisome proliferator-activated nuclear receptors.
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons
The results suggest that cannabinoid-mediated modulation of hippocampal interneuron networks operate largely via presynaptic receptors on CCK-immunoreactive basket cell terminals, the likely mechanism by which both endogenous and exogenous CB1 ligands interfere with hippocampal network oscillations and associated cognitive functions.
Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors
These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors.
GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
- Jane E. Lauckner, Jill B Jensen, H. Chen, Hui-Chen Lu, B. Hille, K. Mackie
- Biology, ChemistryProceedings of the National Academy of Sciences
- 19 February 2008
GPR55 is established as a cannabinoid receptor with signaling distinct from CB1 and CB2, and its signaling pathway is found to involve Gq, G12, RhoA, actin, phospholipase C, and calcium release from IP3R-gated stores.
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity.
- D. Osei-Hyiaman, M. Depetrillo, G. Kunos
- Biology, MedicineThe Journal of clinical investigation
- 2 May 2005
It is concluded that anandamide acting at hepatic CB(1) contributes to diet-induced obesity and that the FAS pathway may be a common molecular target for central appetitive and peripheral metabolic regulation.
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.
Except for its inability to couple to the modulation of Q-type calcium channels or inwardly rectifying potassium channels, the CB1 and CB2 receptors display similar pharmacological and biochemical properties.
Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration
This study identifies a cannabinoid signaling system regulating microglial cell migration and proposes that cannabinol and cannabidiol are promising nonpsychotropic therapeutics to prevent the recruitment of these cells at neuroinflammatory lesion sites.