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ABCB5 gene

Known as: ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 Gene, EST422562, ABCB5beta 
This gene plays a role in both membrane transport and drug resistance.
National Institutes of Health

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ABCB5 wt Allele
Drug EffluxHomo sapiensLigand BindingMolecular Transport

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Wnt/IL‐1β/IL‐8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5
Malignant pleural mesothelioma (MPM) is a tumor with high chemoresistance and poor prognosis. MPM‐initiating cells (ICs) are… 
Review
2018
Review
2018
Expression of Cancer Stem Cell Biomarkers in Human Head and Neck Carcinomas: a Systematic Review
Malignant neoplasms may be composed of several cell groups, including cancer stem cells (CSC). These cells have been related with… 
2015
2015
The c-MYC-ABCB5 axis plays a pivotal role in 5-fluorouracil resistance in human colon cancer cells
c‐MYC overexpression is frequently observed in various cancers including colon cancer and regulates many biological activities… 
Highly Cited
2013
Highly Cited
2013
Markers of circulating tumour cells in the peripheral blood of patients with melanoma correlate with disease recurrence and progression
Background  Multimarker quantitative real‐time polymerase chain reaction (qRT‐PCR) represents an effective method for detecting… 
2013
2013
Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres
Growing evidence suggests that the cancer stem cell phenotype in melanoma is dynamically regulated. Therefore, effective… 
Highly Cited
2012
Highly Cited
2012
Melanoma Chemotherapy Leads to the Selection of ABCB5-Expressing Cells
Metastatic melanoma is the most aggressive skin cancer. Recently, phenotypically distinct subpopulations of tumor cells were… 
Highly Cited
2012
Highly Cited
2012
Expression of human ABCB5 confers resistance to taxanes and anthracyclines.
2010
2010
CD133 and ABCB5 as stem cell markers on sentinel lymph node from melanoma patients.
2010
2010
Immuno-expression of human melanoma stem cell markers in tissues at different stages of the disease.
Review
2009
Review
2009
Cancer Stem Cells: Lessons From Melanoma
The model of cancer stem cells in tumor development states that tumors contain a subset of cells that both self renew and give… 
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