A3309

Irritable bowel syndrome (IBS) and chronic idiopathic constipation ((CIC) also referred to as functional constipation) are two of… Expand

ileal resection for causes other than Crohn ’ s disease) have not been associated with an increased incidence of CRC. In the… Expand

Altered Bile Acid Pool Using IBAT Inhibitors for Constipation: A Potentially Increased Risk of Malignancy 

To the Editor: We read with great interest the article by Chey et al. (1), which demonstrated promising results in the treatment… Expand

OBJECTIVES:Delivery of bile acid (BA) to the colon stimulates propulsive motility and fluid secretion. The objective of this… Expand

OBJECTIVES:A3309 is a minimally absorbed ileal bile acid (BA) transporter (IBAT) inhibitor. We conducted an 8-week, multicenter… Expand

BACKGROUND One half of patients with constipation are not satisfied with available therapies, hence there is a need for more… Expand

3OBJECTIVES: Delivery of bile acid (BA) to the colon stimulates propulsive motility and fl uid secretion. The objective of this… Expand

and symptoms while subjects were at their highest dose (last 7 days of treatment period) versus placebo, adjusting for… Expand

Background: A3309 modulates the enterohepatic circulation of bile acids (BA) by inhibiting the intestinal bile acid transporter… Expand