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A 443654

Known as: A-443654, A443654 
 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Pulmonary artery (PA) smooth muscle cell (SMC) proliferation in pulmonary hypertension (PH) may be linked to dysregulated… Expand
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Highly Cited
2011
Highly Cited
2011
Human malignant glioblastomas are highly invasive tumors. Increased cell motility and degradation of the surrounding… Expand
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Highly Cited
2011
Highly Cited
2011
Phosphorylation of a threonine residue (T308 in Akt1) in the activation loop of Akt kinases is a prerequisite for deregulated Akt… Expand
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Highly Cited
2009
Highly Cited
2009
The kinase Akt plays a central role as a regulator of multiple growth factor input signals, making it an attractive anti-cancer… Expand
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Highly Cited
2009
Highly Cited
2009
A commonly activated signaling cascade in many human malignancies, including glioblastoma multiforme, is the Akt pathway. This… Expand
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2009
2009
Recent reports demonstrate that PKR is constitutively active in a variety of tumors and is required for tumor maintenance and… Expand
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2008
2008
Constitutively activated AKT kinase is a common feature of T-cell acute lymphoblastic leukemia (T-ALL). Here, we report that the… Expand
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2008
2008
Both Akt and Aurora A kinase have been shown to be important targets for intervention for cancer therapy. We report here that… Expand
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Highly Cited
2007
Highly Cited
2007
Rapamycin, a natural product inhibitor of the Raptor-mammalian target of rapamycin complex (mTORC1), is known to induce Protein… Expand
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Highly Cited
2005
Highly Cited
2005
The Akt kinases are central nodes in signal transduction pathways that are important for cellular transformation and tumor… Expand
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