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A 443654

Known as: A-443654, A443654 
National Institutes of Health

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Papers overview

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2017
2017
Novel neurobiological roles of UBE3A
The mechanistic target of rapamycin (mTOR) is a highly conserved and ubiquitously expressed kinase, which consists of two… 
2015
2015
One is akt atp competitive small molecule inhibitors of the synthesis a443654
The present invention discloses a method for synthesizing a small molecule ATP-competitive inhibitors of AKT A443654, the method… 
2015
2015
Downregulation of Mitofusin 2 in Human Mechanism of Activation-Induced
Mitofusin 2 (Mfn2), a mitochondrial protein, was shown to have antiproliferative properties when overexpressed. In this article… 
2010
2010
Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells.
2010
2010
[Effects of insulin and LY294002 inhibitors of PI3K on the regulations and expression of aquaporin 9 in normal liver cells].
OBJECTIVES To explore the effects of insulin on the expression and the regulatory pathway of AQP9 in normal human liver cells… 
2010
2010
American Society of Hematology--51st annual meeting & exposition. Part 1.
The 51st American Society of Hematology (ASH) Annual Meeting and Exposition, held in New Orleans, included topics covering new… 
2008
2008
L 1 . 3 Mutations of the catalytic subunit of class 1 A PI-3 K are constitutively active in hematopoietic cells in vitro and in vivo
Signaling pathways play critical roles in cancer initiating cell (CIC) growth, differentiation, drug resistance and sensitivity… 
2007
2007
Differential regulation of vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors
Levels of vascular endothelial growth factor (VEGF) are regulated, in part, through activation of the phosphatidylinositol 3… 
2007
2007
A Role for Akt in Epidermal Growth Factor-Stimulated Cell Cycle Progression in Cultured Hepatocytes: Generation of a Hyperproliferative Window after Adenoviral Expression of Constitutively Active Akt
Epidermal growth factor (EGF) stimulation of cell cycle progression in cultured primary hepatocytes has previously been reported… 
2007
2007
The AKT Inhibitor, A443654, Induces Cell Cycle Arrest, Apoptosis and Synergizes with Chemotherapeutic Drugs in Multi-Drug Resistant T-Cell Acute Lymphoblastic Leukemia - A Novel Agent for Therapy of…
The PI3K/Akt pathway is a key mediator of proliferation and survival; its constitutive activation is implicated in pathogenesis… 
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