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8-chloroadenosine

Known as: 8-Chloro-adenosine, Adenosine, 8-Chloro-, 8-Cl-adenosine 
An antimetabolite and a chlorine derivative of the purine nucleoside adenosine, with potential antineoplastic activity. Upon administration, 8-chloro… 
National Institutes of Health

Related topics

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2 relations

Broader (1)

2-Chloroadenosine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
A unique RNA-directed nucleoside analog is cytotoxic to breast cancer cells and depletes cyclin E levels
In contrast to deoxyribose or arabinose containing nucleoside analogs that are currently established for cancer therapeutics, 8… 
2010
2010
Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues.
2006
2006
8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells.
2000
2000
Constitutive levels of cAMP‐dependent protein kinase activity determine sensitivity of human multidrug‐resistant leukaemic cell lines to growth inhibition and apoptosis by forskolin and tumour…
The cyclic adenosine monophosphate (cAMP)‐dependent protein kinase (PKA) signal pathway regulates cell proliferation… 
1999
1999
Synergistic interaction between paclitaxel and 8-chloro-adenosine 3',5'-monophosphate in human ovarian carcinoma cell lines.
Taxol is a unique anticancer agent that is used in treatment of advanced ovarian cancer. Taxol exposure results in the… 
1996
1996
Pharmacokinetics, metabolism and tumour disposition of 8-chloroadenosine 3',5'-monophosphate in breast cancer patients and xenograft bearing mice.
BACKGROUND 8-Chloroadenosine 3',5'-monophosphate (8-Cl-cAMP) is undergoing phase I clinical trials as an anticancer drug. However… 
Highly Cited
1993
Highly Cited
1993
8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down-regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent…
The 8-chloro analogue of the regulatory molecule, cyclic AMP (cAMP), modulates the intracellular concentrations of cAMP-dependent… 
1992
1992
Inhibition of colon tumor cell growth by 8‐chloro‐cAMP is dependent upon its conversion to 8‐chloro‐adenosine
Recent interest in site-selective cAMP analogs has focused on the role of 8-chloro-adenosine (8-Cl- adenosine) In the inhibition… 
1992
1992
Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate.
The physiologic balance between the two regulatory subunit isoforms, RI and RII, of cAMP-dependent protein kinase is disrupted in… 
Highly Cited
1988
Highly Cited
1988
Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs.
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