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7-ethyl-10-hydroxycamptothecin glucuronide

Known as: SN-38 glucuronide 
National Institutes of Health

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3 relations

Broader (2)

CamptothecinGlucuronides
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro.
2009
2009
Local enzymatic hydrolysis of an endogenously generated metabolite can enhance CPT-11 anticancer efficacy
Irinotecan (CPT-11) is a clinically important anticancer prodrug that requires enzymatic hydrolysis by carboxyesterase to… 
Highly Cited
2005
Highly Cited
2005
Effects of Ketoconazole on Glucuronidation by UDP-Glucuronosyltransferase Enzymes
Purpose: Ketoconazole has been shown to inhibit the glucuronidation of the UGT2B7 substrates zidovudine and lorazepam. Its effect… 
2004
2004
A Phase I and Pharmacokinetic Study of Irinotecan Given as a 7-Day Continuous Infusion in Metastatic Colorectal Cancer Patients Pretreated with 5-Fluorouracil or Raltitrexed
Purpose: The purpose is to determine the plasma pharmacokinetics, the maximum-tolerable dose and to preliminary evaluate the… 
2003
2003
High-performance liquid chromatographic assay with fluorescence detection for the simultaneous measurement of carboxylate and lactone forms of irinotecan and three metabolites in human plasma.
2003
2003
Pharmacokinetic Study of Two Infusion Schedules of Irinotecan Combined with Cisplatin in Patients with Advanced Gastric Cancer
Objective: Irinotecan (CPT-11) in combination with cisplatin (CDDP) has shown promising antitumor activity for advanced gastric… 
Highly Cited
2002
Highly Cited
2002
Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice
Abstract.Purpose: The extensive and unpredictable biliary excretion of CPT-11 and its metabolites, SN-38 and SN-38 glucuronide… 
Highly Cited
1999
Highly Cited
1999
High-performance liquid chromatographic method for the simultaneous determination of the camptothecin derivative irinotecan hydrochloride, CPT-11, and its metabolites SN-38 and SN-38 glucuronide in…
  • A. KuritaN. Kaneda
  • Journal of Chromatography B: Biomedical Sciences…
  • 1999
  • Corpus ID: 11581405
Highly Cited
1998
Highly Cited
1998
Phase I clinical and pharmacologic study of weekly cisplatin combined with weekly irinotecan in patients with advanced solid tumors.
PURPOSE In vitro synergy between cisplatin and irinotecan (CPT-11) has been reported. We designed a combination schedule of these… 
1995
1995
Pharmacokinetics of SN-38 [(+)-(4S)-4,11-diethyl-4,9-dihydroxy-1H- pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione], an active metabolite of irinotecan, after a single intravenous…
Irinotecan (CPT-11) is a camptothecin derivative used for the treatment of cancer. It is a prodrug that is metabolized to its… 
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