7-ethyl-10-hydroxycamptothecin glucuronide

Known as: SN-38 glucuronide 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2017
051019932017

Papers overview

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Highly Cited
2009
Highly Cited
2009
PURPOSE We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in… (More)
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2008
2008
The coadministration of protease inhibitors with anticancer drugs in the management of human immunodeficiency virus-related… (More)
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2006
2006
Pharmacogenetic testing for UDP-glucuronosyltransferase (UGT) 1A1*28, a promoter variant of the UGT1A1 gene, is now carried out… (More)
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Highly Cited
2002
Highly Cited
2002
The metabolism of irinotecan (CPT-11) involves sequential activation to SN-38 and detoxification to the pharmacologically… (More)
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2002
2002
Irinotecan hydrochloride (CPT-11) is an anticancer agent with unpredictable bouts of diarrhea as a dose-limiting toxic side… (More)
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2002
2002
OBJECTIVE The objective of the study was to develop and validate a population pharmacokinetic model for irinotecan and 2 of its… (More)
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Highly Cited
2000
Highly Cited
2000
This study determined the disposition of irinotecan hydrochloride trihydrate (CPT-11) after i.v. infusion of 125 mg/m(2) (100… (More)
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Highly Cited
1999
Highly Cited
1999
PURPOSE To determine the activity, toxicity, and pharmacokinetics of irinotecan (CPT-11, Camptosar; Pharmacia & Upjohn, Kalamazoo… (More)
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1996
1996
PURPOSE To construct limited-sampling models (LSMs) for irinotecan (CPT-11) pharmacokinetic (PK) measures. MATERIALS AND… (More)
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1993
1993
1. 7-Ethyl-10-[4-(piperidino)-1-piperidino] carbonyloxycamptothecin (CPT-11), a potent anticancer agent currently under… (More)
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