Skip to search formSkip to main contentSkip to account menu

7-ethyl-10-hydroxycamptothecin glucuronide

Known as: SN-38 glucuronide 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

CamptothecinGlucuronides
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Lopinavir–Ritonavir Dramatically Affects the Pharmacokinetics of Irinotecan in HIV Patients With Kaposi's Sarcoma
The coadministration of protease inhibitors with anticancer drugs in the management of human immunodeficiency virus‐related… 
Highly Cited
2005
Highly Cited
2005
Effects of Ketoconazole on Glucuronidation by UDP-Glucuronosyltransferase Enzymes
Purpose: Ketoconazole has been shown to inhibit the glucuronidation of the UGT2B7 substrates zidovudine and lorazepam. Its effect… 
2003
2003
High-performance liquid chromatographic assay with fluorescence detection for the simultaneous measurement of carboxylate and lactone forms of irinotecan and three metabolites in human plasma.
Highly Cited
2002
Highly Cited
2002
Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice
Abstract.Purpose: The extensive and unpredictable biliary excretion of CPT-11 and its metabolites, SN-38 and SN-38 glucuronide… 
2002
2002
Determination of drug interactions occurring with the metabolic pathways of irinotecan.
Irinotecan or CPT-11 [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecine] is a derivative of camptothecine used… 
2001
2001
Phase I dose-finding and pharmacokinetic trial of irinotecan (CPT-11) administered every two weeks.
OBJECTIVES This trial was performed to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and… 
Highly Cited
2000
Highly Cited
2000
Pharmacokinetics of prolonged-release CPT-11-loaded microspheres in rats.
Highly Cited
1999
Highly Cited
1999
High-performance liquid chromatographic method for the simultaneous determination of the camptothecin derivative irinotecan hydrochloride, CPT-11, and its metabolites SN-38 and SN-38 glucuronide in…
  • A. KuritaN. Kaneda
  • Journal of Chromatography B: Biomedical Sciences…
  • 1999
  • Corpus ID: 11581405
Highly Cited
1998
Highly Cited
1998
Phase I clinical and pharmacologic study of weekly cisplatin combined with weekly irinotecan in patients with advanced solid tumors.
PURPOSE In vitro synergy between cisplatin and irinotecan (CPT-11) has been reported. We designed a combination schedule of these… 
Highly Cited
1996
Highly Cited
1996
Limited-sampling models for irinotecan pharmacokinetics-pharmacodynamics: prediction of biliary index and intestinal toxicity.
PURPOSE To construct limited-sampling models (LSMs) for irinotecan (CPT-11) pharmacokinetic (PK) measures. MATERIALS AND… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)