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7-ethyl-10-hydroxycamptothecin glucuronide

Known as: SN-38 glucuronide 
National Institutes of Health

Papers overview

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2009
2009
Irinotecan (CPT-11) is a clinically important anticancer prodrug that requires enzymatic hydrolysis by carboxyesterase to… 
Highly Cited
2005
Highly Cited
2005
Purpose: Ketoconazole has been shown to inhibit the glucuronidation of the UGT2B7 substrates zidovudine and lorazepam. Its effect… 
2004
2004
Purpose: The purpose is to determine the plasma pharmacokinetics, the maximum-tolerable dose and to preliminary evaluate the… 
2003
2003
Objective: Irinotecan (CPT-11) in combination with cisplatin (CDDP) has shown promising antitumor activity for advanced gastric… 
Highly Cited
2002
Highly Cited
2002
Abstract.Purpose: The extensive and unpredictable biliary excretion of CPT-11 and its metabolites, SN-38 and SN-38 glucuronide… 
Highly Cited
1998
Highly Cited
1998
PURPOSE In vitro synergy between cisplatin and irinotecan (CPT-11) has been reported. We designed a combination schedule of these…