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7-ethyl-10-hydroxycamptothecin glucuronide
Known as:
SN-38 glucuronide
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Camptothecin
Glucuronides
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro.
Pankajini Mallick
,
S. Basu
,
B. Moorthy
,
R. Ghose
Toxicology in Vitro
2017
Corpus ID: 4216362
2009
2009
Local enzymatic hydrolysis of an endogenously generated metabolite can enhance CPT-11 anticancer efficacy
Z. Prijovich
,
Kai-Chuan Chen
,
S. Roffler
Molecular Cancer Therapeutics
2009
Corpus ID: 16197005
Irinotecan (CPT-11) is a clinically important anticancer prodrug that requires enzymatic hydrolysis by carboxyesterase to…
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Highly Cited
2005
Highly Cited
2005
Effects of Ketoconazole on Glucuronidation by UDP-Glucuronosyltransferase Enzymes
W. Yong
,
J. Ramírez
,
F. Innocenti
,
M. Ratain
Clinical Cancer Research
2005
Corpus ID: 24811767
Purpose: Ketoconazole has been shown to inhibit the glucuronidation of the UGT2B7 substrates zidovudine and lorazepam. Its effect…
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2004
2004
A Phase I and Pharmacokinetic Study of Irinotecan Given as a 7-Day Continuous Infusion in Metastatic Colorectal Cancer Patients Pretreated with 5-Fluorouracil or Raltitrexed
G. Masi
,
A. Falcone
,
+5 authors
M. del Tacca
Clinical Cancer Research
2004
Corpus ID: 9006863
Purpose: The purpose is to determine the plasma pharmacokinetics, the maximum-tolerable dose and to preliminary evaluate the…
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2003
2003
High-performance liquid chromatographic assay with fluorescence detection for the simultaneous measurement of carboxylate and lactone forms of irinotecan and three metabolites in human plasma.
Thandranese S. Owens
,
H. Dodds
,
K. Fricke
,
S. Hanna
,
K. Crews
Journal of chromatography. B, Analytical…
2003
Corpus ID: 25557180
2003
2003
Pharmacokinetic Study of Two Infusion Schedules of Irinotecan Combined with Cisplatin in Patients with Advanced Gastric Cancer
K. Fujitani
,
T. Tsujinaka
,
M. Hirao
Oncology
2003
Corpus ID: 19468900
Objective: Irinotecan (CPT-11) in combination with cisplatin (CDDP) has shown promising antitumor activity for advanced gastric…
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Highly Cited
2002
Highly Cited
2002
Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice
L. Iyer
,
J. Ramírez
,
+4 authors
U. Mayer
Cancer Chemotherapy and Pharmacology
2002
Corpus ID: 13144916
Abstract.Purpose: The extensive and unpredictable biliary excretion of CPT-11 and its metabolites, SN-38 and SN-38 glucuronide…
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Highly Cited
1999
Highly Cited
1999
High-performance liquid chromatographic method for the simultaneous determination of the camptothecin derivative irinotecan hydrochloride, CPT-11, and its metabolites SN-38 and SN-38 glucuronide in…
A. Kurita
,
N. Kaneda
Journal of Chromatography B: Biomedical Sciences…
1999
Corpus ID: 11581405
Highly Cited
1998
Highly Cited
1998
Phase I clinical and pharmacologic study of weekly cisplatin combined with weekly irinotecan in patients with advanced solid tumors.
L. Saltz
,
D. Spriggs
,
+12 authors
D. Kelsen
Journal of Clinical Oncology
1998
Corpus ID: 11897939
PURPOSE In vitro synergy between cisplatin and irinotecan (CPT-11) has been reported. We designed a combination schedule of these…
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1995
1995
Pharmacokinetics of SN-38 [(+)-(4S)-4,11-diethyl-4,9-dihydroxy-1H- pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione], an active metabolite of irinotecan, after a single intravenous…
R. Atsumi
,
O. Okazaki
,
H. Hakusui
Biological and Pharmaceutical Bulletin
1995
Corpus ID: 25998700
Irinotecan (CPT-11) is a camptothecin derivative used for the treatment of cancer. It is a prodrug that is metabolized to its…
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