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7-ethyl-10-hydroxycamptothecin glucuronide

Known as: SN-38 glucuronide 
 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
PURPOSE We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in… Expand
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2008
2008
The coadministration of protease inhibitors with anticancer drugs in the management of human immunodeficiency virus‐related… Expand
Highly Cited
2006
Highly Cited
2006
Pharmacogenetic testing for UDP‐glucuronosyltransferase (UGT) 1A1*28, a promoter variant of the UGT1A1 gene, is now carried out… Expand
Highly Cited
2004
Highly Cited
2004
A comprehensive haplotype analysis of UGT1A1 in the Japanese population was conducted, and the effects of these haplotypes were… Expand
Highly Cited
2002
Highly Cited
2002
The metabolism of irinotecan (CPT-11) involves sequential activation to SN-38 and detoxification to the pharmacologically… Expand
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Highly Cited
2002
Highly Cited
2002
Irinotecan hydrochloride (CPT-11) is an anticancer agent with unpredictable bouts of diarrhea as a dose-limiting toxic side… Expand
Highly Cited
2002
Highly Cited
2002
Abstract.Purpose: The extensive and unpredictable biliary excretion of CPT-11 and its metabolites, SN-38 and SN-38 glucuronide… Expand
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Highly Cited
2000
Highly Cited
2000
This study determined the disposition of irinotecan hydrochloride trihydrate (CPT-11) after i.v. infusion of 125 mg/m(2) (100… Expand
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Highly Cited
1999
Highly Cited
1999
PURPOSE To determine the activity, toxicity, and pharmacokinetics of irinotecan (CPT-11, Camptosar; Pharmacia & Upjohn, Kalamazoo… Expand
Highly Cited
1996
Highly Cited
1996
PURPOSE A pharmacokinetic study was performed during a phase II clinical trial of irinotecan (CPT-11) to confirm the… Expand