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7-ethyl-10-hydroxycamptothecin glucuronide

Known as: SN-38 glucuronide 
National Institutes of Health

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3 relations

Broader (2)

CamptothecinGlucuronides
analogs & derivatives

Papers overview

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2016
2016
Phase I and pharmacokinetic (PK) study of IHL-305 (pegylated liposomal irinotecan) in patients with advanced solid tumors.
2547 Background: Irinotecan (CPT-11) is a prodrug of SN-38 that has antitumor activity in a wide range of solid tumors. IHL- 305… 
2011
2011
Panipenem does not alter the pharmacokinetics of the active metabolite of irinotecan SN-38 and inactive metabolite SN-38 glucuronide (SN-38G) in rats.
The present study has investigated the effect of panipenem, a widely used antibiotic, on the pharmacokinetics of an active… 
2009
2009
Local enzymatic hydrolysis of an endogenously generated metabolite can enhance CPT-11 anticancer efficacy
Irinotecan (CPT-11) is a clinically important anticancer prodrug that requires enzymatic hydrolysis by carboxyesterase to… 
2003
2003
High-performance liquid chromatographic assay with fluorescence detection for the simultaneous measurement of carboxylate and lactone forms of irinotecan and three metabolites in human plasma.
2003
2003
Pharmacokinetic Study of Two Infusion Schedules of Irinotecan Combined with Cisplatin in Patients with Advanced Gastric Cancer
Objective: Irinotecan (CPT-11) in combination with cisplatin (CDDP) has shown promising antitumor activity for advanced gastric… 
Highly Cited
2002
Highly Cited
2002
Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice
Abstract.Purpose: The extensive and unpredictable biliary excretion of CPT-11 and its metabolites, SN-38 and SN-38 glucuronide… 
2001
2001
Limited sampling models for CPT-11, SN-38, and SN-38 glucuronide
Abstract.Purpose: We developed limited sampling models (LSMs) for predicting the area under the curve (AUC) of irinotecan (CPT-11… 
Highly Cited
1999
Highly Cited
1999
High-performance liquid chromatographic method for the simultaneous determination of the camptothecin derivative irinotecan hydrochloride, CPT-11, and its metabolites SN-38 and SN-38 glucuronide in…
  • A. KuritaN. Kaneda
  • Journal of Chromatography B: Biomedical Sciences…
  • 1999
  • Corpus ID: 11581405
Highly Cited
1998
Highly Cited
1998
Phase I clinical and pharmacologic study of weekly cisplatin combined with weekly irinotecan in patients with advanced solid tumors.
PURPOSE In vitro synergy between cisplatin and irinotecan (CPT-11) has been reported. We designed a combination schedule of these… 
1995
1995
Pharmacokinetics of SN-38 [(+)-(4S)-4,11-diethyl-4,9-dihydroxy-1H- pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione], an active metabolite of irinotecan, after a single intravenous…
Irinotecan (CPT-11) is a camptothecin derivative used for the treatment of cancer. It is a prodrug that is metabolized to its… 
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