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7-deaza-R34

Known as: hammerhead ribozyme 7-deaza-R34 
National Institutes of Health

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1 relation

Broader (1)

Catalytic RNA

Papers overview

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2007
2007
The tolerance to exchanges of the Watson Crick base pair in the hammerhead ribozyme core is determined by surrounding elements.
Tertiary interacting elements are important features of functional RNA molecules, for example, in all small nucleolytic ribozymes… 
2004
2004
Heat capacity changes in RNA folding: application of perturbation theory to hammerhead ribozyme cold denaturation.
In proteins, empirical correlations have shown that changes in heat capacity (DeltaC(P)) scale linearly with the hydrophobic… 
2003
2003
Solvent protection of the hammerhead ribozyme in the ground state: evidence for a cation-assisted conformational change leading to catalysis.
Tertiary folding of the hammerhead ribozyme has been analyzed by hydroxyl radical footprinting. Three hammerhead constructs with… 
2000
2000
Multiple conformational states of the hammerhead ribozyme, broad time range of relaxation and topology of dynamics.
The dynamics of a hammerhead ribozyme was analyzed by measurements of fluorescence-detected temperature jump relaxation. The… 
2000
2000
Significant activity of a modified ribozyme with N7‐deazaguanine at G10.1: the double‐metal‐ion mechanism of catalysis in reactions catalysed by hammerhead ribozymes
Several reports have appeared recently of experimental evidence for a double‐metal‐ion mechanism of catalysis in reactions… 
Highly Cited
1999
Highly Cited
1999
The internal equilibrium of the hairpin ribozyme: temperature, ion and pH effects.
The hairpin ribozyme reversibly cleaves phosphodiesters of RNA substrates to generate products with 5' hydroxyl and 2',3'-cyclic… 
Review
1998
Review
1998
Recent developments in the hammerhead ribozyme field.
Developments in the hammerhead ribozyme field during the last two years are reviewed here. New results on the specificity of this… 
Highly Cited
1998
Highly Cited
1998
Electron paramagnetic resonance spectroscopic measurement of Mn2+ binding affinities to the hammerhead ribozyme and correlation with cleavage activity.
Efficient phosphodiester bond cleavage activity by the hammerhead ribozyme requires divalent cations. Toward understanding this… 
1998
1998
Molecular dynamics study displays near in-line attack conformations in the hammerhead ribozyme self-cleavage reaction.
We have performed molecular dynamics (MD) calculations by using one of the recently solved crystal structures of a hammerhead… 
1998
1998
Cryoenzymology of the hammerhead ribozyme.
The technique of cryoenzymology has been applied to the hammerhead ribozyme in an attempt to uncover a structural rearrangement… 
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