6-pyruvoyltetrahydropterin synthase activity

Known as: PTPS activity, 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity, 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming) 
Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate. [EC:4.2.3.12, RHEA:22051… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2013
0119912013

Papers overview

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2014
2014
Escherichia coli 6-carboxytetrahydropterin synthase (eCTPS), a homologue of 6-pyruvoyltetrahydropterin synthase (PTPS), possesses… (More)
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2013
Review
2013
Breast cancer is linked to hyperactivation of protein tyrosine kinases (PTKs), and recent studies have unveiled that selective… (More)
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2006
2006
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Proficiency testing programs (PTPs) have long been recognized as a tool that accreditation bodies and regulatory authorities… (More)
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2003
2003
Biosynthesis of (6 R )-5,6,7,8-tetrahydro-L-biopterin (H(4)-biopterin), an essential cofactor for aromatic amino acid… (More)
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Review
2000
Review
2000
Phosphorylation of proteins on tyrosine acts as a reversible and specific ‘switching’ mechanism, forming or disrupting regulatory… (More)
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1999
1999
6-Pyruvoyltetrahydropterin synthase (PTPS) participates in tetrahydrobiopterin cofactor biosynthesis. We previously identified in… (More)
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1998
1998
BACKGROUND The nitric oxide synthase cofactor tetrahydrobiopterin (BH4) is involved in the regulation of endothelium-dependent… (More)
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1996
1996
Sir: Transient neonatal tyrosinaemia is thought to be caused by late maturation of the hepatic enzymes 4-hydroxyphenylpyruvate… (More)
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1991
Review
1991
We investigated intracellular pteridine concentrations, activities of pteridine biosynthetic enzymes and formation of nitrogen… (More)
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