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6-pyruvoyltetrahydropterin synthase activity

Known as: PTPS activity, 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity, 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming) 
Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate. [EC:4.2.3.12, RHEA:22051… 
National Institutes of Health

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6-pyruvoyltetrahydropterin synthase

Papers overview

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1996
1996
Tetrahydrobiopterin induced neonatal tyrosinaemia
Sir: Transient neonatal tyrosinaemia is thought to be caused by late maturation of the hepatic enzymes 4-hydroxyphenylpyruvate… 
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