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6-codeinone

Known as: codeinone 
National Institutes of Health

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2 relations

Broader (1)

Codeine
analogs & derivatives

Papers overview

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2015
2015
A and morphine synthesis 1 Cytochrome P 450 3 A Enzymes Catalyze the O 6-Demethylation of Thebaine , a Key Step in Endogenous Mammalian Morphine Biosynthesis
Morphine, first characterized in opium from the poppy Papaver somniferum, is one of the strongest known analgesics. Endogenous… 
Review
2004
Review
2004
6-oxo-morphinane oximes: pharmacology, chemistry and analytical application.
The permanent therapeutic importance of morphine derivatives in pain treatment has inspired continual synthetic efforts to modify… 
1991
1991
Studies on the biotransformation of codeinone to codeine by cell cultures of Papaver somniferum
  • J. Goy
  • 1991
  • Corpus ID: 112205493
1985
1985
Analgesics of the 6,14-ethenomorphinan type. 6-deoxy-7 alpha-orvinols and 6-deoxy-8 alpha-orvinols.
6-Deoxythebaine (3) has been prepared as a precursor to C-6 alkyl substituted orvinols 15 and 17. The C-6 methyl group was… 
1981
1981
Analgesic narcotic antagonists. 6. 7 beta, 8 beta-Methano- and 7 beta, 8 beta-epoxydihydrocodeinone.
Reaction of codeinone (2) with CH2N2 in the presence of Pd(OAc)2 yielded mixtures of starting material and (2) and 7 beta, 8 beta… 
1980
1980
Analgesic narcotic antagonists. 1. 8 beta-Alkyl-, 8 beta-acyl-, and 8 beta-(tertiary alcohol)dihydrocodeinones and -dihydromorphinones.
Conjugate addition of lithium dialkyl cuprates to codeinone (3) gave as the major product a series of 8 beta… 
1976
1976
A practical synthesis of codeine from dihydrothebainone.
The conversion of dihydrothebainone to codeine or thebaine has been achieved in high yield. Bromination and dehydrobromination… 
1972
1972
Transformations in the morphine series. 5. Reaction of codeinone with dimethyloxosulfonium methylide. Structure and analgetic activity of the product and its reduced form.
1971
1971
Synthesis of new codeinone and indolinocodeinone derivatives
Derivatives of both 14-hydroxycodeinone and the Diels-Alder adducts of thebaine provide some of the most potent analgesics in the… 
1967
1967
Codeinone as the intermediate in the biosynthetic conversion of thebaine to codeine.
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