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5-hydroxypropranolol

National Institutes of Health

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Propranolol
analogs & derivatives

Papers overview

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2016
2016
Salting-out assisted extraction method coupled with hydrophilic interaction liquid chromatography for determination of selected β-blockers and their metabolites in human urine.
Highly Cited
2009
Highly Cited
2009
Regioselective preparation of 5-hydroxypropranolol and 4'-hydroxydiclofenac with a fungal peroxygenase.
2002
2002
CATALYTIC SPECIFICITY OF CYP 2 D ISOFORMS IN RAT AND HUMAN
In rats, six cytochrome P450 (P450) 2D isoforms have been genetically identified. Nonetheless, there is little evidence of… 
2000
2000
Species difference in enantioselectivity for the oxidation of propranolol by cytochrome P450 2D enzymes.
2000
2000
Neonatal hepatic propranolol elimination: studies in the isolated perfused neonatal sheep liver.
Using the isolated perfused neonatal sheep liver model, we examined the disposition of propranolol (n = 8, age 0.25-10 days) and… 
1994
1994
Metabolic kinetics of pseudoracemic propranolol in human liver microsomes. Enantioselectivity and quinidine inhibition.
The enantioselective formation kinetics of 4-hydroxypropranolol (4-HOP), 5-hydroxypropranolol (5-HOP), and… 
1987
1987
The formation of glutathione conjugate derived from propranolol.
Mixed function oxidases in liver microsomes from 3-methylcholanthrene-pretreated guinea pigs converted S-propranolol to 4… 
1977
1977
Cardiovascular effects of 5-hydroxypropranolol (ORF 12592) in dogs.
ORF 12592, the 5-hydroxy analog of propranolol, produced reductions in mean arterial pressure, heart rate, cardiac contractility… 
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