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5-hydroxymethylomeprazole

Known as: 5-hydroxy omeprazole, 5-methoxy-2-(((4-methoxy-3-methyl-5-hydroxymethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole, hydroxyomeprazole 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

2-Pyridinylmethylsulfinylbenzimidazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Increased omeprazole metabolism in carriers of the CYP2C19*17 allele; a pharmacokinetic study in healthy volunteers.
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT The only existing study of CYP2C19*17-associated alterations in drug pharmacokinetics… 
Highly Cited
2000
Highly Cited
2000
No sex‐related differences but significant inhibition by oral contraceptives of CYP2C19 activity as measured by the probe drugs mephenytoin and omeprazole in healthy Swedish white subjects
Although it is known that the use of oral contraceptives inhibits oxidative drug metabolism, there is little information… 
Highly Cited
1998
Highly Cited
1998
Artemisinin induces omeprazole metabolism in human beings
Highly Cited
1998
Highly Cited
1998
Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype
Highly Cited
1996
Highly Cited
1996
CYP2C19 genotype and phenotype determined by omeprazole in a Korean population.
Omeprazole (20 mg orally) was given to 103 healthy Korean subjects and blood was taken 3 h after administration. The plasma… 
Highly Cited
1995
Highly Cited
1995
Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians: comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype.
A single oral dose of omeprazole (20 mg) was given orally to 160 healthy Caucasian Swedish subjects and tested as a probe for… 
Highly Cited
1995
Highly Cited
1995
Interphenotype differences in disposition and effect on gastrin levels of omeprazole--suitability of omeprazole as a probe for CYP2C19.
1. Fourteen healthy Swedish Caucasian subjects were given 20 mg of omeprazole orally each morning for 8 days. The subjects… 
Highly Cited
1994
Highly Cited
1994
Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism.
1. The in vitro metabolism of omeprazole was studied in human liver microsomes in order to define the secondary metabolic… 
Highly Cited
1993
Highly Cited
1993
Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism.
1 The in vitro metabolism of omeprazole was studied in human liver microsomes in order to define the metabolic pathways and… 
Highly Cited
1992
Highly Cited
1992
Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects.
Twelve Caucasian healthy men and women, of whom six were poor metabolizers (PMs) and six were extensive metabolizers (EMs) of S… 
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