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5-hydroxymethylomeprazole

Known as: 5-hydroxy omeprazole, 5-methoxy-2-(((4-methoxy-3-methyl-5-hydroxymethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole, hydroxyomeprazole 
 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT The only existing study of CYP2C19*17-associated alterations in drug pharmacokinetics… Expand
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Highly Cited
1998
Highly Cited
1998
This study investigated whether time‐dependent artemisinin pharmacokinetics correlated to CYP3A4 or CYP2C19 activity in vivo. 
Highly Cited
1996
Highly Cited
1996
Omeprazole (20 mg orally) was given to 103 healthy Korean subjects and blood was taken 3 h after administration. The plasma… Expand
Highly Cited
1995
Highly Cited
1995
A single oral dose of omeprazole (20 mg) was given orally to 160 healthy Caucasian Swedish subjects and tested as a probe for… Expand
Highly Cited
1995
Highly Cited
1995
1. Fourteen healthy Swedish Caucasian subjects were given 20 mg of omeprazole orally each morning for 8 days. The subjects… Expand
Highly Cited
1994
Highly Cited
1994
1. The in vitro metabolism of omeprazole was studied in human liver microsomes in order to define the secondary metabolic… Expand
Highly Cited
1993
Highly Cited
1993
1 The in vitro metabolism of omeprazole was studied in human liver microsomes in order to define the metabolic pathways and… Expand
Highly Cited
1992
Highly Cited
1992
Twelve Caucasian healthy men and women, of whom six were poor metabolizers (PMs) and six were extensive metabolizers (EMs) of S… Expand
Highly Cited
1990
Highly Cited
1990
The pharamacokinetics of omeprazole, hydroxyomeprazole, omeprazolesulfone, and “remaining metabolites” have been studied in eight… Expand
Review
1989
Review
1989
Omeprazole is acid labile and, therefore, has to be protected from exposure to the acidic gastric juice when given orally… Expand