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Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans
TLDR
Significant differences in CYP1A2 enzyme activity between Swedes and Koreans that could not be explained by environmental factors or the CYP 1A2 haplotypes examined are found, despite differences in allele frequencies. Expand
Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism.
TLDR
The results show that the UGT2B17 polymorphism is strongly associated with the bimodal distribution of the testosterone excretion and also with the large differences inosterone excretion between Koreans and Swedes. Expand
4&bgr;-Hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians
TLDR
Evidence is given that the plasma concentration of 4&bgr;-hydroxycholesterol may be used as an endogenous marker of CYP3A activity (CYP3A4+5), which was shown in the three major human races. Expand
Risperidone metabolism in relation to CYP2D6*10 allele in Korean schizophrenic patients
TLDR
In Korean schizophrenic patients, the metabolism of risperidone is dependent on CYP2D6, and the CYP1D6*10 allele is important for the regulation of the activity of this enzyme, which suggests that the clinical significance of this polymorphism is limited. Expand
CYP2C19 activity comparison between Swedes and Koreans: effect of genotype, sex, oral contraceptive use, and smoking
TLDR
Controlling for the effect of genotype and sex, Koreans display lower CYP2C19 activity than Swedes, and the genetic, epigenetic or environmental basis for this difference remains to be identified. Expand
CYP2C19 genotype and phenotype determined by omeprazole in a Korean population.
TLDR
A high incidence of PMs of omeprazole in Koreans is confirmed and of the 32 Korean PMs 97% could be identified by the genotype analysis, and only one PM subject was found to be heterozygous for the *1 and *2 alleles. Expand
Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects.
TLDR
The present pilot study revealed major similarities in the polymorphic CYP2D locus between Korean, Japanese and Chinese populations. Expand
Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450.
TLDR
Production of desmethylranitidine by rat and human liver microsomes was inhibited by tranylcypromine, a-naphthoflavon and quinidine, which are known to inhibit CYP2C19, 1A2 and 2D6, repectively. Expand
Genetic aspects of epitestosterone formation and androgen disposition: influence of polymorphisms in CYP17 and UGT2B enzymes
TLDR
The data indicate that 5-androstene-3&bgr;, 17&agr;-diol is an important precursor of epitestosterone and that CYP17 is involved in its production. Expand
Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FM03 gene mutations in a Korean population.
TLDR
The results showed that subjects who were homozygous and heterozygous for either one or both of the FMO3/Lys158 and F MO3/Gly308 mutant alleles had significantly lower in-vivo FMO activities than those with homozygotes wild-type alleles. Expand
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