2-Pyridinylmethylsulfinylbenzimidazoles

Known as: Sulfoxides, Benzimidazole Methylpyridine, 2 Pyridinylmethylsulfinylbenzimidazoles, Benzimidazole Methylpyridine Sulfoxides 
Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1964-2018
0204019642018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Here, we describe the identification of a clinical candidate via structure-based optimization of a ligand efficient pyrazole… (More)
  • figure 1
  • table 1
  • figure 3
  • figure 2
  • table 2
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Polo-like kinase 1 (PLK1) plays key roles in the regulation of mitotic progression, including mitotic entry, spindle formation… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2001
Highly Cited
2001
The tumor suppressor phosphatase PTEN regulates cell migration, growth, and survival by dephosphorylating phosphatidylinositol… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1996
Highly Cited
1996
1. Hippocampal long-term potentiation (LTP) may serve as an elementary process underlying certain forms of learning and memory in… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Camptothecin is an S-phase-specific anticancer agent that inhibits the activity of the enzyme DNA topoisomerase-I (topo-I… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Alpha-Amanitin is a well-known specific inhibitor of RNA polymerase II (RNAPII) in vitro and in vivo. It is a cyclic octapeptide… (More)
Is this relevant?
Highly Cited
1990
Highly Cited
1990
The primary cytotoxic mechanism of camptothecin has been proposed to involve an interaction between the replication machinery and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Highly Cited
1984
Highly Cited
1984
Exposure of intact cells to UV light brings about cross-linking of polyadenylated mRNA to a set of cytoplasmic proteins which are… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
1979
Highly Cited
1979
The kinetic constants for the hydrolysis of a series of I-nitroanilide substrates by human leukocyte (HL) elastase and cathepsin… (More)
  • table I
  • table II
Is this relevant?