Skip to search formSkip to main contentSkip to account menu

5-hydroxymethyl tolterodine

National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Benzhydryl CompoundsCresols

Narrower (1)

PNU 200577

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
[A role of fesoterodine in treatment of overactive bladder].
The muscarinic receptors have been used as target in treatment of overactive bladder (OAB) for a long time. These patients have… 
2016
2016
Effects of combination treatment with fesoterodine and mirabegron on urinary bladder functions of pelvic congestion model in rats
Hypothesis / aims of study Muscarinic receptor antagonists and β3 adrenoceptor agonist are the currently recommended medicines… 
2016
2016
Physiologically Based Pharmacokinetic Modeling & Simulation Using Simcyp to Predict Drug-Drug Interaction When Mirabegron is Co-administered with Fesoterodine
Hypothesis / aims of study Fesoterodine (4 or 8 mg once daily (QD)), an antimuscarinic (1), and mirabegron (25 or 50 mg QD), a β3… 
2016
2016
Relaxant effects of combination treatment with fesoterodine and mirabegron: An in-vitro study using detrusor strips from the stroke model and pelvic congestion model in rats
Hypothesis / aims of study Medicines with different mode of actions (MOA) such as antimuscarinics and β3 agonist, are available… 
2014
2014
The effects of tolterodine and 5-hydroxymethyl tolterodine (5HMT) on carbachol-induced contraction in human bladder smooth muscles in normal state and in detrusor overactivity associated with benign…
Hypothesis / aims of study Tolterodine is an antimuscarinic drug and is converted to 5-HMT by the cytochrome P450 (CYP) 2D6… 
2014
2014
CHARACTERIZATION OF MUSCARINIC RECEPTOR BINDING OF FESOTERODINE AFTER ORAL ADMINISTRATION IN RATS
  • 2014
  • Corpus ID: 34718327
Hypothesis / aims of study Fesoterodine is a relatively novel antimuscarinic agent for the treatment of overactive bladder (OAB… 
2013
2013
Effects of fesoterodine metabolite on excitability of the neurotransmitter in cultured urothelial cells from bladder outlet obstruction (BOO) rat
Hypothesis / aims of study The urothelium is important to manifest the OAB symptoms in BOO and the expression changes of various… 
2011
2011
A randomized study to assess the action of fesoterodine on urethral function in women with stress urinary incontinence using urethral pressure reflectometry
Hypothesis / aims of study Pre-clinical studies in anesthetized dogs suggest that the active metabolite of fesoterodine (5… 
2007
2007
Dose response relationship of fesoterodine 4 mg vs 8 mg and onset of action in subjects with overactive bladder: results from a pooled analysis of 2 randomized trials
Hypothesis / aims of study Although clinical studies suggest that many patients with overactive bladder (OAB) who are…