5-hydroxydantrolene
National Institutes of Health
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The pharmacokinetics of dantrolene and its active metabolite, 5-hydroxydantrolene, after a single oral dose of either 5 or 10 mg…
Dantrolene is a skeletal muscle relaxant used commonly in performance horses to prevent exertional rhabdomyolysis. The goal of…
SummaryIdentified metabolites of dantrolene, a skeletal muscle relaxant, were studied for inhibition of skeletal muscle…
The role of individual rat liver cytochrome P-450 isozymes in the metabolism of the skeletal muscle relaxant, dantrolene, was…
Dantrolene, a direct acting muscle relaxant used orally for spasticity, has appeared to be effective in the prevention and…
To determine the pharmacokinetics of iv dantrolene and its metabolites in children, ten children 2-7 yr of age scheduled for…
SummarySynopsis: Dantrolene sodium1 acts primarily by affecting calcium flux across the sarcoplasmic reticulum of skeletal muscle…
Serum concentration of dantrolene and its active metabolite, 5-hydroxydantrolene were determined in 27 cerebral palsy patients…