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5-fluorouridine 5'-triphosphate

Known as: FUTP, uridine 5'-(tetrahydrogen triphosphate), 5-fluoro- 
National Institutes of Health

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Broader (1)

Uridine Triphosphate
analogs & derivatives

Papers overview

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2015
2015
Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.
1997
1997
Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
To explore the determinants of cytotoxicity during prolonged exposure to pharmacologically relevant concentrations of 5… 
Highly Cited
1996
Highly Cited
1996
Reduced Activity of Anabolizing Enzymes in 5‐Fluorouracil‐resistant Human Stomach Cancer Cells
The mechanism of resistance to 5‐fluorouracil (5‐FU) was studied with NUGC‐3/5FU/L, a human stomach cancer cell line which had… 
1996
1996
The cellular interaction of 5-fluorouracil and cisplatin in a human colon carcinoma cell line.
Highly Cited
1995
Highly Cited
1995
Thymidine Phosphorylase Mediates the Sensitivity of Human Colon Carcinoma Cells to 5-Fluorouracil (*)
Interferon-α (IFNα) potentiates the antitumor activity of 5-fluorouracil (FUra) in colon cancer in vitro, in vivo, and clinically… 
Highly Cited
1989
Highly Cited
1989
Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo.
19F-magnetic resonance spectroscopy (MRS) can be used to non-invasively monitor metabolism of 5-fluorouracil (5FU) to cytotoxic… 
Highly Cited
1988
Highly Cited
1988
5-Fluorouracil substitution alters pre-mRNA splicing in vitro.
Highly Cited
1981
Highly Cited
1981
Selective activation of 5'-deoxy-5-fluorouridine by tumor cells as a basis for an improved therapeutic index.
The intracellular metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine (5'-dFUrd), was compared with the metabolism of… 
Highly Cited
1980
Highly Cited
1980
Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine.
5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The… 
1980
1980
The effect of 5-fluorouridine 5'-triphosphate on RNA transcribed in isolated nuclei in vitro.
Using nuclei prepared from rat liver, the effect of 5-fluorouridine 59-triphosphate (FUTP) was assessed on the nearest neighbor… 
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