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5-fluorouridine 5'-triphosphate

Known as: FUTP, uridine 5'-(tetrahydrogen triphosphate), 5-fluoro- 
National Institutes of Health

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Broader (1)

Uridine Triphosphate
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Locoregional administration of 5-fluoro-2′-deoxyuridine (FdUrd) in Novikoff hepatoma in the rat: effects of dose and infusion time on tumor growth and on FdUrd metabolite levels in tumor tissue as…
SummaryThe influence of infusion time and dose on the anticancer efficacy of 5-fluoro-2′-deoxyuridine (FdUrd) was investigated… 
2000
2000
Monitoring of the intracellular activation of 5‐fluorouracil to deoxyribonucleotides in HT29 human colon cell line: application to modulation of metabolism and cytotoxicity study
Abstract— An HPLC method was developed for in vitro detection and monitoring of intracellular metabolites of [3H]‐5‐fluorouracil… 
1998
1998
Mechanisms for 5-fluorouracil resistance in human colon cancer DLD-1 cells.
A 5-fluorouracil (5-FU)-resistant subline, DLD-1/5-FU, was established by repeated 5-d exposures of human colon cancer DLD-1… 
1997
1997
Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
To explore the determinants of cytotoxicity during prolonged exposure to pharmacologically relevant concentrations of 5… 
1996
1996
The cellular interaction of 5-fluorouracil and cisplatin in a human colon carcinoma cell line.
1996
1996
Phase I study of N-(phosphonacetyl)-L-aspartate with fluorouracil and with or without dipyridamole in patients with advanced cancer.
We conducted a combined biochemical modulation trial of N-(phosphonacetyl)-L-aspartate (PALA), dipyridamole (DP), and… 
1984
1984
Substrate properties of 5-fluorouridine diphospho sugars detected in hepatoma cells.
1982
1982
Pyrimidine nucleoside phosphorylase activity in tumour and matched normal gastrointestinal mucosa.
5-Fluorouracil (5-FU) requires activation to the metabolites FdUMP and FUTP for its cytotoxic effect. This activation involves… 
Highly Cited
1981
Highly Cited
1981
Selective activation of 5'-deoxy-5-fluorouridine by tumor cells as a basis for an improved therapeutic index.
The intracellular metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine (5'-dFUrd), was compared with the metabolism of… 
Highly Cited
1980
Highly Cited
1980
Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine.
5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The… 
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