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Fluoropyrimidines such as 5-fluorouracil (5-FU) form the foundation of a wide variety of chemotherapy regimens. 5-FU is in fact… Expand The mechanism of resistance to 5‐fluorouracil (5‐FU) was studied with NUGC‐3/5FU/L, a human stomach cancer cell line which had… Expand Interferon-α (IFNα) potentiates the antitumor activity of 5-fluorouracil (FUra) in colon cancer in vitro, in vivo, and clinically… Expand Interferon-alpha (IFN alpha) increases the cytotoxicity of 5-fluorouracil (FUra) in vitro, and the combination has clinical… Expand After more than three decades since their introduction, fluoropyrimidines, especially FUra, are still a mainstay in the treatment… Expand This is a review on the mechanism of action of FUra. Three main areas are addressed: metabolism, RNA-directed actions of FUra… Expand 19F-magnetic resonance spectroscopy (MRS) can be used to non-invasively monitor metabolism of 5-fluorouracil (5FU) to cytotoxic… Expand We are interested in determining whether incorporation of the drug 5-fluorouracil into pre-mRNA can alter RNA processing. The… Expand The intracellular metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine (5'-dFUrd), was compared with the metabolism of… Expand 5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The… Expand