5,8-dideazaisopteroylglutamate
National Institutes of Health
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SummaryThe folate analogue 5,8-dideazaisopteroylglutamate (IAHQ; NSC-289517) inhibits the growth of a variety of human tumor…
A human T-lymphoblast cell line, CCRF-CEM/R1, resistant to methotrexate by virtue of increased dihydrofolate reductase activity…
Abstract The effects of 5,8-dideazaisopteroylglutamate ( N -[ p -{[(2-amino-4-hydroxy-6-quinazolinyl)amino]methyl}benzoyl]-l…
A series of 2-amino-4-hydroxy-quinazolines was synthesized and evaluated as inhibitors of colon adenocarcinoma and the folate…