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5,8-dideazaisofolic acid

Known as: IAHQ 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

5,8-dideazaisopteroylglutamate

Broader (1)

Quinazolines

Papers overview

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2000
2000
A comparison of the effects of nine folate analogs on early and late murine hematopoietic progenitor cells in vitro
Purpose: Since the clinical introduction of the antifolates aminopterin (AMT) and methotrexate (MTX) many promising analogs have… 
1986
1986
Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
The effects of 5-fluoro-2'-deoxyuridine (FdUrd) and 5,8-dideazaisofolic acid on the coordination of thymidylate synthase activity… 
1985
1985
Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine.
In the preceding companion paper, we describe a human colon carcinoma cell line that is resistant in vitro to 5-fluoro-2… 
1984
1984
Improved synthesis and antitumor evaluation of 5,8-dideazaisofolic acid and closely related analogues.
A new synthetic route to 5,8-dideazaisofolic acid (IAHQ) is described which precludes the possibility of contamination due to its… 
1984
1984
Effects of three new folate antagonists on human breast adenocarcinoma cells in vitro and on immune responses in vivo.
The effects of three selected potential folate antagonists on 3H-leucine incorporation of eight established breast adenocarcinoma… 
1983
1983
Improved synthetic routes to 5,8-dideazapteroylglutamates amenable to the formation of poly-gamma-L-glutamyl derivatives.
A variety of quinazoline analogues of folic acid (5,8-dideazafolates) are of interest as potential antineoplastic agents… 
1982
1982
Effects of 5,8-dideazaisofolic acid (IAHQ) on human tumor cells in culture and on normal and tumor-bearing hamsters.
The quinazoline analog of folic acid, 5,8-dideazaisofolic acid (IAHQ), was tested for its effects on the growth of human tumor… 
1981
1981
5,8-Dideazaisofolic acid