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5,8-dideazaisofolic acid

Known as: IAHQ 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

5,8-dideazaisopteroylglutamate

Broader (1)

Quinazolines

Papers overview

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1993
1993
Synthesis and biological evaluation of analogues of 5,8-dideazaisofolic acid (IAHQ) modified at positions 2, 4 and 9.
The compound 5,8-dideazaisofolic acid (IAHQ), 1a, was found to posses modest antitumor activity against a variety of human and… 
1987
1987
Mechanism of action of 5,8-dideazaisofolic acid and other quinazoline antifols in human colon carcinoma cells.
The clonal cytotoxic effects and mechanism of action of a new series of 2-amino-4-hydroxyquinazoline folate analogues (5,8… 
1986
1986
Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
The effects of 5-fluoro-2'-deoxyuridine (FdUrd) and 5,8-dideazaisofolic acid on the coordination of thymidylate synthase activity… 
1986
1986
Endogenous thymidine and hypoxanthine are a source of error in evaluating methotrexate cytotoxicity by clonogenic assays using undialyzed fetal bovine serum.
None of 13 fresh human tumor samples of various histology cloned in a two-layer agar culture system with 20% undialyzed fetal… 
Highly Cited
1985
Highly Cited
1985
Cytotoxic effects of folate antagonists against methotrexate-resistant human leukemic lymphoblast CCRF-CEM cell lines.
A human T-lymphoblast cell line, CCRF-CEM/R1, resistant to methotrexate by virtue of increased dihydrofolate reductase activity… 
1984
1984
Improved synthesis and antitumor evaluation of 5,8-dideazaisofolic acid and closely related analogues.
A new synthetic route to 5,8-dideazaisofolic acid (IAHQ) is described which precludes the possibility of contamination due to its… 
1983
1983
Biochemical and antitumor effects of 5,8-dideazaisopteroylglutamate, a unique quinazoline inhibitor of thymidylate synthase.
Abstract The effects of 5,8-dideazaisopteroylglutamate ( N -[ p -{[(2-amino-4-hydroxy-6-quinazolinyl)amino]methyl}benzoyl]-l… 
1983
1983
Improved synthetic routes to 5,8-dideazapteroylglutamates amenable to the formation of poly-gamma-L-glutamyl derivatives.
A variety of quinazoline analogues of folic acid (5,8-dideazafolates) are of interest as potential antineoplastic agents… 
1982
1982
Effects of 5,8-dideazaisofolic acid (IAHQ) on human tumor cells in culture and on normal and tumor-bearing hamsters.
The quinazoline analog of folic acid, 5,8-dideazaisofolic acid (IAHQ), was tested for its effects on the growth of human tumor… 
1981
1981
5,8-Dideazaisofolic acid
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