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5,8-dideazafolic acid

Known as: N-(p-(((2-amino-4-hydroxy-6-quinazolinyl)methyl)amino)benzoyl)-L-glutamic acid 
National Institutes of Health

Papers overview

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1998
1998
Quinoxaline chemistry. Part 10. Quinoxaline 10-oxa-analogues of trimetrexate (TMQ) and of 5,8-dideazafolic acid. Synthesis and evaluation of in vitro anticancer activity.
1993
1993
Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583).
1991
1991
Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues.
We report the synthesis of four new 4-thio-5,8-dideazafolic acid analogues and a 4-(methylthio) analogue structurally related to… 
1989
1989
Relative substrate activities of structurally related pteridine, quinazoline, and pyrimidine analogs for mouse liver folylpolyglutamate synthetase.
Several structurally related series of folate analogs were studied as substrates for mouse liver folylpolyglutamate synthetase… 
1988
1988
Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin.
A series of 5,8-dideaza analogues of folic acid, isofolic acid, aminopterin, and isoaminopterin were evaluated for inhibition of… 
1988
1988
Early DNA damage induced in cells exposed to N10-propargyl 5,8-dideazafolic acid (CB 3717) or methotrexate.
1986
1986
Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF…
The poly-gamma-glutamyl derivatives of n10-propargyl-5,8-dideazafolic acid (PDDF) with a chain length of up to five glutamate… 
1986
1986
Synthesis of 10-acetyl-5,8-dideazafolic acid: a potent inhibitor of glycinamide ribonucleotide transformylase.
10-Acetyl-5,8-dideazafolic acid has been synthesized in good yield from the parent compound, 5,8-dideazafolic acid. This… 
1986
1986
Metabolism of N/sup 10/-(propargyl) 5,8-dideazafolic acid (PDDF) to poly-. gamma. -glutamates in mice
The antileukemic agent, PDDF is a very potent inhibitor of thymidylate synthase (TS). It has been shown to be a good substrate of… 
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