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Synthesis of 10-acetyl-5,8-dideazafolic acid: a potent inhibitor of glycinamide ribonucleotide transformylase.
This quinazoline folate analogue showed no activity as a substrate for the folate-requiring de novo purine biosynthetic enzyme glycinamide ribonucleotide transformylase isolated from the murine lymphoma cell line L5178Y, but proved to be a potent competitive inhibitor.
Hybrid methodologies for small scale engineering
  • J. Conigliaro
  • Business
    IEMC'01 Proceedings. Change Management and the…
  • 7 October 2001
In order to successfully control development in a small-scale engineering firm, a middle ground between the formal-methods utilized in large organizations and the ad-hoc approach used by many
Early Pattern Classification Using Partial Pattern Matching
The study indicates that a basic partial pattern matching technique may be used to perform early classification of a day’s usage for the purposes of detecting anomalous data.