5,6-dihydroxy-2-indolylcarboxylic acid

Melanins can be classified into two major groups-insoluble brown to black pigments termed eumelanin and alkali-soluble yellow to… Expand

We report the results of an experimental and theoretical study of the electronic and structural properties of a key eumelanin… Expand

Macrophage migration inhibitory factor (MIF) is a cytokine that was first described as an inhibitor of the random migration of… Expand

Mammalian melanins exist in two chemically distinct forms: the brown to black eumelanins and the yellow to reddish pheomelanins… Expand

Mammalian melanocytes can produce two basic types of melanin, eumelanin and pheomelanin, within discrete organelles termed… Expand

Since the characterization of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) as a major melanogenic intermediate, the fate of this… Expand

Several genes critical to the enzymatic regulation of melanin production in mammals have recently been cloned and mapped to the… Expand

The production of melanin pigment in mammals requires tyrosinase, an enzyme which hydroxylates the amino acid tyrosine to DOPA (3… Expand

The regulation of the final steps of the melanogenesis pathway, after L-2-carboxy-2,3-dihydroindole-5,6-quinone (dopachrome… Expand

The generally accepted concept that the black melanin eumelanin is made mostly from 5,6-dihydroxyindole but not from 5,6… Expand