5,6-dihydroxy-2-indolylcarboxylic acid

Known as: 5,6-dihydroxyindole-2-carboxylic acid, DHI2C, 5,6-DHICA 
 
National Institutes of Health

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Review
2008
Review
2008
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
Melanins can be classified into two major groups-insoluble brown to black pigments termed eumelanin and alkali-soluble yellow to… (More)
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2006
2006
Chemical and structural disorder in eumelanins: a possible explanation for broadband absorbance.
We report the results of an experimental and theoretical study of the electronic and structural properties of a key eumelanin… (More)
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2005
2005
Comparisons of the structural and chemical properties of melanosomes isolated from retinal pigment epithelium, iris and choroid of newborn and mature bovine eyes.
Melanosomes were isolated from the retinal pigment epithelium (RPE), iris and choroid of mature (age >2 years) and newborn (age… (More)
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2001
2001
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
Melanin synthesis in mammals is catalysed by at least three enzymic proteins, tyrosinase (monophenol dihydroxyphenylalanine… (More)
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2001
2001
Variation in melanin content and composition in type V and VI photoexposed and photoprotected human skin: the dominant role of DHI.
A combination of techniques, including high-performance liquid chromatography (HPLC), spectrophotometric measurements, and a… (More)
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1999
1999
Enzymatically inactive macrophage migration inhibitory factor inhibits monocyte chemotaxis and random migration.
Macrophage migration inhibitory factor (MIF) is a cytokine that was first described as an inhibitor of the random migration of… (More)
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Highly Cited
1995
Highly Cited
1995
Modulation of melanogenic protein expression during the switch from eu- to pheomelanogenesis.
Mammalian melanocytes can produce two basic types of melanin, eumelanin and pheomelanin, within discrete organelles termed… (More)
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Highly Cited
1995
Highly Cited
1995
Chemical characterization of hair melanins in various coat-color mutants of mice.
Mammalian melanins exist in two chemically distinct forms: the brown to black eumelanins and the yellow to reddish pheomelanins… (More)
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Highly Cited
1994
Highly Cited
1994
Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis.
Several genes critical to the enzymatic regulation of melanin production in mammals have recently been cloned and mapped to the… (More)
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Highly Cited
1994
Highly Cited
1994
A new enzymatic function in the melanogenic pathway. The 5,6-dihydroxyindole-2-carboxylic acid oxidase activity of tyrosinase-related protein-1 (TRP1).
Since the characterization of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) as a major melanogenic intermediate, the fate of this… (More)
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