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5'-methylthioadenosine

Known as: 5'-deoxy-5'-(methylthio)adenosine, 5'-methylthio-5'-deoxyadenosine, adenine(5'-deoxy-5'-methylthio)9-beta-D-furanoriboside 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

AntimalarialsDeoxyadenosinesEnzyme InhibitorsThionucleosides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Neutron structures of the Helicobacter pylori 5′-methylthioadenosine nucleosidase highlight proton sharing and protonation states
Significance Gastrointestinal infection by the bacterium Helicobacter pylori is strongly associated with the development of… 
2008
2008
Structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
5'-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) catalyzes the irreversible cleavage of the glycosidic bond in 5… 
Highly Cited
2005
Highly Cited
2005
Structural Rationale for the Affinity of Pico- and Femtomolar Transition State Analogues of Escherichia coli 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase*♦
Immucillin and DADMe-Immucillin inhibitors are tight binding transition state mimics of purine nucleoside phosphorylases (PNP). 5… 
Highly Cited
2004
Highly Cited
2004
Inhibition of lipopolysaccharide-stimulated TNF-α promoter activity by S-adenosylmethionine and 5′-methylthioadenosine
S-adenosylmethionine (SAM) is the principal biological methyl donor and precursor for polyamines. SAM is known to be… 
Review
2002
Review
2002
Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine.
1998
1998
Enzyme-mediated cytosine deamination by the bacterial methyltransferase M.MspI.
Most prokaryotic (cytosine-5)-DNA methyltransferases increase the frequency of deamination at the cytosine targeted for… 
Review
1997
Review
1997
Parasite sulphur amino acid metabolism.
Highly Cited
1993
Highly Cited
1993
Urinary excretion of modified nucleosides as biological marker of RNA turnover in patients with cancer and AIDS.
1985
1985
The metabolism of 5'-methylthioadenosine and 5-methylthioribose 1-phosphate in Saccharomyces cerevisiae.
Cordycepin sensitive mutants of Saccharomyces cerevisiae, which are permeable to 5'-deoxy-5'-methylthioadenosine (MTA), were used… 
Highly Cited
1977
Highly Cited
1977
Polyamine biosynthesis in rat prostate. Substrate and inhibitor properties of 7-deaza analogues of decarboxylated S-adenosylmethionine and 5'-methylthioadenosine.
The 7-deaza analogue of 5'-methylthioadenosine, a nucleoside end product in polyamine biosynthesis, has been synthesized. This… 
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