4-iodopyrazole

Known as: 4-iodo-1H-pyrazole 
 
National Institutes of Health

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Pyrazoles

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2016
2016
Rapid experimental SAD phasing and hot-spot identification with halogenated fragments
Through X-ray crystallographic fragment screening, 4-bromopyrazole was discovered to be a 'magic bullet' that is capable of… (More)
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2015
2015
Experimental and DFT Study on the Compounds [PdCl2L2] (L = 4-methylpyrazole, 4-iodopyrazole).
Theoretical molecular structures of the complexes [PdCl(2)(HmPz)(2)] (1) and [PdCl(2)(HIPz)(2)] (2) (HmPz = 4-methylpyrazole… (More)
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2003
2003
Axial ligand complexes of the Rhodnius nitrophorins: reduction potentials, binding constants, EPR spectra, and structures of the 4-iodopyrazole and imidazole complexes of NP4
Previously, we utilized 4-iodopyrazole (4IPzH) as a heavy atom derivative for the initial solution of the crystal structure of… (More)
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1998
1998
Induction of CYP2A5 by pyrazole and its derivatives in mouse primary hepatocytes
Mouse liver CYP2A5 is induced by several structurally unrelated compounds. In intact mouse liver, pyrazole (PYR) and 4… (More)
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1994
1994
Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences.
The three-dimensional structures of three variants of human beta alcohol dehydrogenase have been determined to 2.5 A resolution… (More)
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1991
1991
Inducibility of P450Coh by pyrazole and its derivatives.
Pyrazole and several of its derivatives increase the hepatic microsomal coumarin 7-hydroxylase to a variable extent. The… (More)
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1987
1987
Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo
Using a hybrid ion-exchange reverse phase HPLC system, we found that F344 rat liver microsomes, in the presence of an NADPH… (More)
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1986
1986
Observations on the biochemical basis of ethanol metabolism by human macrophages.
The metabolism of ethanol (0.1 and 1.0 mg/ml) to acetate by blood-monocyte-derived macrophages was only slightly inhibited by… (More)
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1982
1982
Pyrazole binding in crystalline binary and ternary complexes with liver alcohol dehydrogenase.
Pyrazole is a strong inhibitor of liver alcohol dehydrogenase in combination with oxidized coenzyme NAD+. We have studied three… (More)
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1976
1976
Effect of pyrazole, 4-methylpyrazole, 4-bromopyrazole and 4-iodopyrazole on brain noradrenaline levels of mice and rats.
Four daily doses of pyrazole (50 mg/kg), caused a reduction in rat brain noradrenaline (NA) of over 20% when determined 24 hrs… (More)
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