4-hydroxy-N-desmethyltamoxifen

Known as: 4-hydroxy-N-demethyltamoxifen, Endoxifen 
 
National Institutes of Health

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Broader (1)

Tamoxifen
analogs & derivatives

Papers overview

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2012
2012
Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide
Tamoxifen dosage is based on the one-dose-fits-all approach. The anticancer effect of tamoxifen is believed to be due to the… (More)
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2010
2010
A convenient synthesis of (Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen).
A mixture of the (Z)- and (E)-isomers of 4-hydroxy-N-desmethyltamoxifen was conveniently prepared in four steps. These… (More)
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Highly Cited
2009
Highly Cited
2009
Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.
CONTEXT The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is… (More)
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Highly Cited
2006
Highly Cited
2006
Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells.
We recently demonstrated that endoxifen (4-hydroxy-N-desmethyl-tamoxifen), a pharmacogenetically regulated metabolite of… (More)
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Highly Cited
2006
Highly Cited
2006
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.
BACKGROUND AND OBJECTIVES N-Desmethyltamoxifen (NDM), a major primary metabolite of tamoxifen, is hydroxylated by cytochrome P450… (More)
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Highly Cited
2005
Highly Cited
2005
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes.
PURPOSE Polymorphisms in tamoxifen metabolizing genes affect the plasma concentration of tamoxifen metabolites, but their effect… (More)
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Highly Cited
2005
Highly Cited
2005
CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.
BACKGROUND The efficacy of tamoxifen therapy for the treatment of breast cancer varies widely among individuals. Plasma… (More)
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Highly Cited
2004
Highly Cited
2004
Pharmacological Characterization of 4-hydroxy-N-desmethyl Tamoxifen, a Novel Active Metabolite of Tamoxifen
The antiestrogen tamoxifen is extensively metabolized in patients to form a series of compounds with altered affinity for… (More)
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Highly Cited
2004
Highly Cited
2004
Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen
Tamoxifen is an effective drug for the treatment and prevention of breast cancer. It is extensively metabolized by the human… (More)
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Highly Cited
2003
Highly Cited
2003
Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.
BACKGROUND Tamoxifen, a selective estrogen receptor modulator (SERM), is converted to 4-hydroxy-tamoxifen and other active… (More)
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