4-hydroxy-N-desmethyltamoxifen

Known as: 4-hydroxy-N-demethyltamoxifen, Endoxifen 
 
National Institutes of Health

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2012
2012
Tamoxifen dosage is based on the one-dose-fits-all approach. The anticancer effect of tamoxifen is believed to be due to the… (More)
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2010
2010
A mixture of the (Z)- and (E)-isomers of 4-hydroxy-N-desmethyltamoxifen was conveniently prepared in four steps. These… (More)
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Highly Cited
2009
Highly Cited
2009
CONTEXT The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is… (More)
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Highly Cited
2006
Highly Cited
2006
We recently demonstrated that endoxifen (4-hydroxy-N-desmethyl-tamoxifen), a pharmacogenetically regulated metabolite of… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND AND OBJECTIVES N-Desmethyltamoxifen (NDM), a major primary metabolite of tamoxifen, is hydroxylated by cytochrome P450… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE Polymorphisms in tamoxifen metabolizing genes affect the plasma concentration of tamoxifen metabolites, but their effect… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND The efficacy of tamoxifen therapy for the treatment of breast cancer varies widely among individuals. Plasma… (More)
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Highly Cited
2004
Highly Cited
2004
The antiestrogen tamoxifen is extensively metabolized in patients to form a series of compounds with altered affinity for… (More)
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Highly Cited
2004
Highly Cited
2004
Tamoxifen is an effective drug for the treatment and prevention of breast cancer. It is extensively metabolized by the human… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Tamoxifen, a selective estrogen receptor modulator (SERM), is converted to 4-hydroxy-tamoxifen and other active… (More)
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