Skip to search formSkip to main contentSkip to account menu

4-hydroxy-2-nonenal

Known as: 4-HNE cpd, 4 hydroxynonenal, 4-hydroxynonen-2-al 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

AldehydesCross-Linking ReagentsCysteine Proteinase Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction
Oxidative stress is implicated in neuronal apoptosis that occurs in physiological settings and in neurodegenerative disorders… 
Highly Cited
1998
Highly Cited
1998
Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal.
During the progression of certain degenerative conditions, including myocardial ischemia-reperfusion injury, mitochondria are a… 
Highly Cited
1997
Highly Cited
1997
4‐Hydroxy‐2‐Nonenal Pyrrole Adducts in Human Neurodegenerative Disease
Increasing age and inheritance of the ∈4 allele of apolipoprotein E (APOE4) are significant risk factors for sporadic and late… 
Highly Cited
1997
Highly Cited
1997
Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4…
Abstract: Deposits of amyloid β‐peptide (Aβ), reduced glucose uptake into brain cells, oxidative damage to cellular proteins and… 
Highly Cited
1996
Highly Cited
1996
Presence of hypochlorite-modified proteins in human atherosclerotic lesions.
Oxidation of LDL may contribute to atherogenesis, though the nature of the in vivo oxidant(s) remains obscure. Myeloperoxidase… 
Highly Cited
1994
Highly Cited
1994
Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease.
Incubation of glucose-6-phosphate dehydrogenase (Glu-6-PDH) from Leuconostoc mesenteroides with the lipid peroxidation product 4… 
Highly Cited
1994
Highly Cited
1994
Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins: markers for atherosclerosis.
It has been proposed that plasma low-density lipoprotein (LDL) undergoes oxidative modification before it can give rise to foam… 
Highly Cited
1993
Highly Cited
1993
Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction.
Review
1989
Review
1989
Methods for determination of aldehydic lipid peroxidation products.
Highly Cited
1987
Highly Cited
1987
Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes.
The alteration of structural and biological properties of human plasma low density lipoprotein (LDL) exposed to oxidative… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)