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Ectodomain shedding is a proteolytic mechanism by which transmembrane molecules are converted into a soluble form. Cleavage is… Expand HER2 is a ligand-less tyrosine kinase receptor of the ErbB family that is frequently overexpressed in breast cancer. It undergoes… Expand Here we report the inhibition of cellular invasion by a recombinant mouse endostatin and the possible mechanism of the inhibition… Expand Matrix metalloproteinase 7 (MMP-7) has been purified as an inactive zymogen of Mr 28,000 (proMMP-7) from the culture medium of… Expand Matrix metalloproteinase 9 (MMP-9) has been purified as an inactive zymogen of M(r) 92,000 (proMMP-9) from the culture medium of… Expand Transformed human fibroblasts secrete two structurally and functionally related inhibitors of matrix metalloproteinases, tissue… Expand Human rheumatoid synovial cells in culture secrete at least three related metalloproteinases that digest extracellular matrix… Expand The latent forms of stromelysin and collagenase from human gingival fibroblasts were purified to homogeneity. These latent… Expand Human rheumatoid synovial cells in culture stimulated with the conditioned culture medium of rabbit macrophages secrete three… Expand Rabbit synovial fibroblasts induced to undergo a specific switch in gene expression by agents that alter cell morphology secreted… Expand