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Interactions between cancer cells and the endothelium in metastasis
- F. Orr, H. Wang, R. Lafrenie, S. Scherbarth, D. M. Nance
- Medicine, Biology
- The Journal of pathology
- 1 February 2000
The haematogenous phase of cancer metastasis facilitates the transport of metastatic cells within the blood and incorporates a sequence of interactions between circulating intravascular cancer cells… Expand
Interactions of cancer cells with the microvasculature during metastasis 1 2
Metastasis of cancer via the bloodstream is a major factor in the diagnosis, treatment, and prognosis of patients with cancer. Key events in hematogenous metastasis occur in the microvasculature.… Expand
Increased expression of activated matrix metalloproteinase-2 by human endothelial cells after sublethal H2O2 exposure.
- A. Belkhiri, C. Richards, M. Whaley, S. McQueen, F. Orr
- Biology, Medicine
- Laboratory investigation; a journal of technical…
- 1 November 1997
Basement membranes form a boundary between intravascular and extravascular compartments that is remodeled by matrix metalloproteinases (MMP) expressed by endothelial cells. These cells are at risk of… Expand
Pathophysiologic interactions in skeletal metastasis
This review summarizes evidence that the formation of bone metastases is the result of multiple synergistic cellular and molecular interactions between metastatic cells and the unique… Expand
C‐myc gene expression alone is sufficient to confer resistance to antiestrogen in human breast cancer cells
C‐myc is implicated in the initiation, progression and estrogen response of breast cancer. To further investigate the role of c‐myc in breast cancer, we have developed clonal MCF‐7 human breast… Expand
Inhibition of SV40 T antigen-induced hepatocellular carcinoma in TIMP-1 transgenic mice.
- D. C. Martin, U. Rüther, O. Sanchezsweatman, F. Orr, R. Khokha
- Biology, Medicine
- 1 August 1996
The potential of tissue inhibitors of metalloproteinases (TIMPs) to inhibit neoplastic progression has been postulated from studies of genetically manipulated cells. To investigate whether the TIMP-1… Expand
Intravital videomicroscopic evidence for regulation of metastasis by the hepatic microvasculature: effects of interleukin-1alpha on metastasis and the location of B16F1 melanoma cell arrest.
There have been few reported visual observations of metastatic cancer cell arrest in vivo. To seek evidence that inducible vascular adhesive properties can regulate hepatic metastasis, groups of 9-14… Expand
The potential role for prolactin-inducible protein (PIP) as a marker of human breast cancer micrometastasis
SummaryThe prolactin-inducible protein (PIP/GCPD15) is believed to originate from a limited set of tissues, including breast and salivary glands, and has been applied as a clinical marker for the… Expand
Walker 256 tumor cell degradation of extracellular matrices involves a latent gelatinase activated by reactive oxygen species.
- S. Shaughnessy, M. Whaley, R. Lafrenie, F. Orr
- Chemistry, Medicine
- Archives of biochemistry and biophysics
- 1 August 1993
The invasion of blood vessel walls is a critical step in cancer metastasis, in which endothelial cells and their vascular basement membranes act as barriers to tumor cell passage. Here we report that… Expand
Direct osteolysis induced by metastatic murine melanoma cells: role of matrix metalloproteinases.
We examined the osteolytic ability of metastatic cells and the role of tumour matrix metalloproteinases (MMPs) in bone degradation. The histomorphometry of experimental bone metastases of B16/F1… Expand