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Tumor necrosis factor-alpha stimulates the biosynthesis of matrix metalloproteinases and plasminogen activator in cultured human chorionic cells.
The results suggested that TNF alpha may participate in destruction of collagen and other connective tissue matrix components of fetal membranes and in promotion of uterine contractility in preterm parturition with intraamniotic infection. Expand
Tumor-stromal cell contact promotes invasion of human uterine cervical carcinoma cells by augmenting the expression and activation of stromal matrix metalloproteinases.
- Takashi Sato, Takeaki Sakai, Yutaka Noguchi, M. Takita, S. Hirakawa, A. Ito
- Biology, Medicine
- Gynecologic oncology
Cell-cell contact between cervical carcinoma cells and peripheral stromal fibroblasts augments the production and activation of M MPs, and therefore the subsequent imbalance between MMPs and TIMPs may result in the progression of invasiveness of cervical carcinomas cells in vivo. Expand
Glycosaminoglycans of human uterine cervix: heparan sulfate increase with reference to cervical ripening.
A marked increase in heparan sulfate and a decrease in dermatAn sulfate was confirmed in the cervix in pregnancy at term, and a marked increase and decrease in glycosaminoglycans in the tissue changed markedly. Expand
Human recombinant interleukin‐ 1α increases biosynthesis of collagenase and hyaluronic acid in cultured human chorionic cells
It is proposed that IL‐1 from effused leukocytes in fetal membranes plays an important role in connective tissue metabolism, especially in premature rupture of membranes with chorioamnionitis. Expand
Ovarian wedge resection with contact Nd:YAG laser irradiation used laparoscopically.
- E. Kojima, A. Yanagibori, K. Otaka, S. Hirakawa
- The Journal of reproductive medicine
- 1 July 1989
It seems that the decrease in intraovarian androgens might have reduced the negative feedback system and thus might have increased the secretion of gonadotropin and estradiol, which in turn promoted ovulation induction and pregnancy. Expand
The treatment of unruptured tubal pregnancy with intratubal methotrexate injection under laparoscopic control.
- E. Kojima, Y. Abe, M. Morita, M. Ito, S. Hirakawa, K. Momose
- Obstetrics and gynecology
- 1 April 1990
Nine patients with unruptured tubal pregnancies of 6-9 weeks' duration were treated with methotrexate intratubal injection under laparoscopic control, with a median time of 11 days (range 1-29) to resolution. Expand
Suppression of apoptotic cell death progressed in vitro with incubation of the chorion laeve tissues of human fetal membrane by glucocorticoid.
- K. Ohyama, K. Oka, +5 authors T. Yamakawa
- Biology, Medicine
- Biological & pharmaceutical bulletin
- 15 October 1998
It is revealed that a substantial proportion of trophoblast cells in the chorion laeve of human fetal membranes are induced to undergo apoptosis at the end of pregnancy, and that the apoptosis progresses rapidly in vitro as the incubation period increases. Expand
Changes in the human uterine cervical collagenase with special reference to cervical ripening.
Both active collagenase and the complex of collagenase with α 2 -macroglobulin were found to increase more significantly in pregnancy at term than those in nonpregnant control group and the inactive enzyme estimated by activation did not change during the course of pregnancy. Expand
Increased prostacyclin synthesizing activity in human ripening uterine cervix.
The 6-ketoprostaglandin F1 alpha production in the ripening cervix was more than 6 times per wet weight and 37 times per DNA as much as that in the non-pregnant cervix. Expand
The change in solubility of type I collagen in human uterine cervix in pregnancy at term.
Both decrease in collagen concentration and increased in type I collagen solubility are important factors to induce the cervical dilatation and effacement in pregnancy at term. Expand