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3-methoxymorphinan

Known as: LK-3 compound, morphinan, 3-methoxy- 
National Institutes of Health

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4 relations

Narrower (2)

3-methoxymorphinan hydrochloride3-methoxymorphinan, (14alpha)-isomer

Broader (1)

Dextromethorphan
analogs & derivatives

Papers overview

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2015
2015
The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans
AbstractThe use of khat (Catha edulis) while on medication may alter treatment outcome. In particular, the influence of khat on… 
2009
2009
A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its…
Dextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activity in vivo and in vitro. A SIM GC/MS method… 
2007
2007
The spinal anaesthetic effect of dextromethorphan, dextrorphan, and 3-methoxymorphinan.
2007
2007
Effects of dextrorotatory morphinans on brain Na+ channels expressed in Xenopus oocytes.
2003
2003
New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice.
2002
2002
A sensitive LC-MS/MS assay for the determination of dextromethorphan and metabolites in human urine--application for drug interaction studies assessing potential CYP3A and CYP2D6 inhibition.
2002
2002
Effect of interferon α‐ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N‐acetyltransferase‐2 activities in patients with chronic active hepatitis C
Interferon α (IFN‐α) is thought to be responsible for cytochrome P450 (CYP)‐dependent drug interactions mediated by a decrease in… 
2002
2002
Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells
1. The aim was to compare the metabolic activity of human CYP3A4 expressed in bacteria (E. coli), yeast (S. cerevisiae) and human… 
Highly Cited
2001
Highly Cited
2001
Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6.
The O-demethylation of dextromethorphan to dextrorphan in humans is catalyzed primarily by cytochrome P450 2D6 (CYP2D6). However… 
1994
1994
Screening for hydroxylation and acetylation polymorphisms in man via simultaneous analysis of urinary metabolites of mephenytoin, dextromethorphan and caffeine by capillary electrophoretic procedures…
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