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3-methoxymorphinan

Known as: LK-3 compound, morphinan, 3-methoxy- 
National Institutes of Health

Papers overview

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2007
2007
Dextromethorphan, an antitussive, has a complex pharmacologic profile and has not been well studied. Our aim was to evaluate… Expand
2002
2002
Interferon α (IFN‐α) is thought to be responsible for cytochrome P450 (CYP)‐dependent drug interactions mediated by a decrease in… Expand
Highly Cited
2002
Highly Cited
2002
The objective of this study was to determine the effects of grapefruit juice and seville orange juice on dextromethorphan (DM… Expand
Highly Cited
2000
Highly Cited
2000
The aims of these experiments were to determine the effect of a therapeutic regimen of dexamethasone on cytochrome P4503A4… Expand
Highly Cited
1999
Highly Cited
1999
The ability of antipsychotic drugs to inhibit the catalytic activity of five cytochrome P-450 (CYP) isoforms was compared using… Expand
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Highly Cited
1998
Highly Cited
1998
Cytochromes mediating the biotransformation of dextromethorphan to dextrorphan and 3‐methoxymorphinan, its principal metabolites… Expand
Highly Cited
1997
Highly Cited
1997
The human clearance of omeprazole and lansoprazole is conducted primarily by the hepatic cytochrome P450 (CYP) system. Efficacy… Expand
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Highly Cited
1996
Highly Cited
1996
We studied the disposition of dextromethorphan in extensive and poor metabolizer subjects, as well as the effect of this… Expand
Highly Cited
1993
Highly Cited
1993
The metabolism of dextromethorphan, a drug used to probe genetically determined CYP2D6 activity has been investigated in vivo and… Expand
Highly Cited
1990
Highly Cited
1990
A simple, sensitive, and reproducible high-performance liquid chromatrography assay is described for the simultaneous… Expand