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The critical period of valproate exposure to induce autistic symptoms in Sprague-Dawley rats.
It is suggested that E12 is the critical period in rats when valproate exposure has prominent effects for inducing the altered social behavior similar to human autistic behavior. Expand
Effects of Ethanol Exposure During Early Pregnancy in Hyperactive, Inattentive and Impulsive Behaviors and MeCP2 Expression in Rodent Offspring
The results suggest that prenatal exposure to EtOH induces hyperactive, inattentive and impulsive behaviors in rodent offspring that might be related to global epigenetic changes as well as aberration in catecholamine neurotransmitter transporter system. Expand
Induction of matrix metalloproteinase‐9 (MMP‐9) in lipopolysaccharide‐stimulated primary astrocytes is mediated by extracellular signal‐regulated protein kinase 1/2 (Erk1/2)
The results from the present study suggest that induction of MMP‐9 by LPS in rat primary astrocytes is mediated, at least in part, by the sequential activation of PKC and Erk1/2. Expand
Chronic exposure to ethanol of male mice before mating produces attention deficit hyperactivity disorder‐like phenotype along with epigenetic dysregulation of dopamine transporter expression in mouse
It is suggested that preconceptional exposure to EtOH through the paternal route induces behavioral changes in offspring, possibly via epigenetic changes in gene expression, which is essential for the regulation of ADHD‐like behaviors. Expand
Subchronic Treatment of Donepezil Rescues Impaired Social, Hyperactive, and Stereotypic Behavior in Valproic Acid-Induced Animal Model of Autism
Evidence is provided that dysregulation of ACh system represented by the up-regulation of acetylcholinesterase (AChE) may serve as an effective pharmacological therapeutic target against autistic behaviors in VPA animal model of ASD, which should be subjected for further investigation to verify the clinical relevance. Expand
Male‐specific alteration in excitatory post‐synaptic development and social interaction in pre‐natal valproic acid exposure model of autism spectrum disorder
The results suggest that prenatally VPA‐exposed rats show the male preponderance of ASD‐like behaviors including defective social interaction similar to human autistic patients, which might be caused by ectopic increase in glutamatergic synapses in male rats. Expand
Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis.
Results indicate that the anticonvulsive effects produced by wogonin were mediated by the GABAergic neuron. Expand
Platycodin D and D3 increase airway mucin release in vivo and in vitro in rats and hamsters.
The results from the present study suggest that platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases. Expand
Depletion of intracellular glutathione mediates zinc-induced cell death in rat primary astrocytes
  • J. Ryu, C. Shin, +4 authors K. Ko
  • Chemistry, Medicine
  • Experimental Brain Research
  • 26 January 2002
ROS generation, GSH depletion and mitochondrial dysfunction may be key factors in Zn2+-induced glial toxicity. Expand