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3-(2,4-dimethoxybenzylidene)anabaseine

Known as: Dimethoxybenzylidene anabaseine, DMXB-Anabaseine, DMXBA 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Benzylidene CompoundsNicotinic AgonistsPyridines

Narrower (1)

GTS-21

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Human Brain Imaging of α7 nAChR with [18F]ASEM: a New PET Radiotracer for Neuropsychiatry and Determination of Drug Occupancy
PurposeUsing the α7-nAChR radiotracer, [18F]ASEM, we present the first successful human positron emission tomography (PET… 
Highly Cited
2011
Highly Cited
2011
Effects of an Alpha 7-Nicotinic Agonist on Default Network Activity in Schizophrenia
Highly Cited
2009
Highly Cited
2009
A reversible model of the cognitive impairment associated with schizophrenia in monkeys: potential therapeutic effects of two nicotinic acetylcholine receptor agonists.
Highly Cited
2006
Highly Cited
2006
The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties
Nemertines are a phylum of carnivorous marine worms that possess a variety of alkaloidal, peptidic or proteinaceous toxins that… 
Highly Cited
2004
Highly Cited
2004
Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and…
3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (DMXBA; GTS-21), an Alzheimer's drug candidate, selectively stimulates… 
Review
2000
Review
2000
The brain α7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21)
Highly Cited
1998
Highly Cited
1998
Selective α7-nicotinic agonists normalize inhibition of auditory response in DBA mice
Abstract Abnormal sensory inhibition is a measurable indicator of a sensory processing deficit which is observed in schizophrenia… 
Highly Cited
1998
Highly Cited
1998
Neuroprotective and memory-related actions of novel alpha-7 nicotinic agents with different mixed agonist/antagonist properties.
The goals of this study were to develop compounds that were selective and highly efficacious agonists at alpha-7 receptors, while… 
Highly Cited
1998
Highly Cited
1998
Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat alpha-7 nicotinic receptors.
3-(2,4-dimethoxybenzylidene)anabaseine (GTS-21) is a selective partial agonist for rat alpha-7 nicotine receptors with reportedly… 
Highly Cited
1998
Highly Cited
1998
Nicotinic alpha 7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage.
The alpha7 receptor agonist dimethoxybenzylidene anabaseine (DMXB) protected rat neocortical neurons against excitotoxicity… 
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