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GTS-21

Known as: GTS 21 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
The anti-inflammatory properties of, particularly the α7, nicotinic acetylcholine receptors (nAChRs) in the peripheral immune… Expand
Review
2011
Review
2011
Neuronal nicotinic acetylcholine receptors (nAChR), recognized targets for drug development in cognitive and neuro-degenerative… Expand
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Highly Cited
2009
Highly Cited
2009
The cholinergic antiinflammatory pathway modulates Inflammatory cytokine production through a mechanism dependent on the vagus… Expand
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Highly Cited
2009
Highly Cited
2009
The vagus nerve can limit inflammation via the alpha7 nicotinic acetylcholine receptor (alpha7nAChR). Selective pharmacological… Expand
Highly Cited
2007
Highly Cited
2007
Objective:Tumor necrosis factor and high mobility group box 1 are critical cytokine mediators of inflammation. The efferent vagus… Expand
Highly Cited
2003
Highly Cited
2003
This study was designed to determine the safety, tolerability, pharmacokinetics and effects on cognitive function of GTS-21 in… Expand
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Review
2000
Review
2000
  • W. Kem
  • Behavioural Brain Research
  • 2000
  • Corpus ID: 39523754
A large decrease in brain nicotinic receptor levels occurs in Alzheimer's disease, relative to muscarinic and other receptors… Expand
Highly Cited
1997
Highly Cited
1997
(2.4)-Dimethoxybenzylidene anabaseine dihydrochloride (GTS-21), a compound that interacts with rat neuronal nicotinic… Expand
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Highly Cited
1995
Highly Cited
1995
The ability of two synthetic nicotine receptor ligands, TGS-21 and DMAB, to chronically enhance the cognitive function of aged… Expand
Highly Cited
1994
Highly Cited
1994
The septo-hippocampal cholinergic system is of demonstrated involvement in eyeblink classical conditioning (EBCC). To determine… Expand