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GTS-21

Known as: GTS 21 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

3-(2,4-dimethoxybenzylidene)anabaseine

Papers overview

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Highly Cited
2014
Highly Cited
2014
The α7 Nicotinic Acetylcholine Receptor Agonist GTS-21 Improves Bacterial Clearance in Mice by Restoring Hyperoxia-Compromised Macrophage Function
Mechanical ventilation with supraphysiological concentrations of oxygen (hyperoxia) is routinely used to treat patients with… 
Highly Cited
2010
Highly Cited
2010
Whole blood cytokine attenuation by cholinergic agonists ex vivo and relationship to vagus nerve activity in rheumatoid arthritis
Abstract.  Bruchfeld A, Goldstein RS, Chavan S, Patel NB, Rosas‐Ballina M, Kohn N, Qureshi AR, Tracey KJ. (Karolinska Institute… 
Highly Cited
2009
Highly Cited
2009
A reversible model of the cognitive impairment associated with schizophrenia in monkeys: potential therapeutic effects of two nicotinic acetylcholine receptor agonists.
Highly Cited
2006
Highly Cited
2006
The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice.
BACKGROUND & AIMS The nervous system, through the vagus nerve, controls inflammation by decreasing the release of tumor necrosis… 
Highly Cited
2006
Highly Cited
2006
The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties
Nemertines are a phylum of carnivorous marine worms that possess a variety of alkaloidal, peptidic or proteinaceous toxins that… 
Highly Cited
2004
Highly Cited
2004
Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and…
3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (DMXBA; GTS-21), an Alzheimer's drug candidate, selectively stimulates… 
Highly Cited
1998
Highly Cited
1998
Selective α7-nicotinic agonists normalize inhibition of auditory response in DBA mice
Abstract Abnormal sensory inhibition is a measurable indicator of a sensory processing deficit which is observed in schizophrenia… 
Highly Cited
1998
Highly Cited
1998
Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils.
The neuroprotective effects of GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride] were studied and compared with… 
Highly Cited
1998
Highly Cited
1998
Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands.
Highly Cited
1997
Highly Cited
1997
3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat α7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner
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