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GTS-21

Known as: GTS 21 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

3-(2,4-dimethoxybenzylidene)anabaseine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
EFFECT OF GTS-21, AN ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCED INFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN MICE
Background: During abdominal sepsis, the inhibition of gastrointestinal (GI) motility together with mucosal barrier dysfunction… 
2012
2012
Lipopolysaccharide Upregulates &agr;7 Acetylcholine Receptors: STIMULATION WITH GTS-21 MITIGATES GROWTH ARREST OF MACROPHAGES AND IMPROVES SURVIVAL IN BURNED MICE
Nicotinic stimulation of the &agr;7 acetylcholine receptors (&agr;7AChRs) mitigates the lipopolysaccharide (LPS)–induced tumor… 
2012
2012
Discovery of novel α7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs.
2010
2010
Activation of α7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-α7 nAChR-hAPP695 cells
Highly Cited
2004
Highly Cited
2004
The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors.
The alpha7 nAChR-selective partial agonist 3-(2,4-dimethoxybenzylidene)anabaseine (GTS-21) is more efficacious and potent for rat… 
2000
2000
Nicotinic modulation in an animal model of a form of associative learning impaired in Alzheimer’s disease
2000
2000
Genetic and pharmacological strategies identify a behavioral function of neuronal nicotinic receptors
2000
2000
A nicotinic cholinergic agonist (GTS-21) and eyeblink classical conditioning: acquisition, retention, and relearning in older rabbits.
Previously we demonstrated that GTS-21, a nicotinic cholinergic agonist, ameliorated eyeblink classical conditioning deficits in… 
Highly Cited
1998
Highly Cited
1998
Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands.
1998
1998
GTS-21, a nicotinic agonist, attenuates multiple infarctions and cognitive deficit caused by permanent occlusion of bilateral common carotid arteries in rats.
We examined the effects of GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], a nicotinic agonist, on… 
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