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3'-hydroxyamobarbital

Known as: 5-ethyl-5-(3-hydroxy-3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione 
National Institutes of Health

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Amobarbital
analogs & derivatives

Papers overview

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1983
1983
The occurrence of two hepatic microsomal sites for amobarbital hydroxylation.
Amobarbital metabolism in human liver and in rat liver, lung, kidney, and small intestine was measured in vitro using thin-layer… 
1980
1980
Species differences of amobarbital metabolism: dihydroxyamobarbital formation.
Amobarbital is almost completely metabolized in animals and man. The major metabolite is 3'-hydroxyamobarbital. The second major… 
Review
1979
Review
1979
A method for studying drug metabolism in populations: Racial differences in amobarbital metabolism
The two main metabolites of amobarbital excreted in urine are 3′‐hydroxyamobarbital (C‐OH) and 1‐(β‐D‐glucopyranosyl) amobarbital… 
1978
1978
Distinctive patterns of amobarbital metabolites
This paper establishes that the relative proportion of amobarbital metabolites in urine is highly variable from person to person… 
1977
1977
Amobarbital metabolism in man. Determination of N-hydroxyamobarbital and 3'-hydroxyamobarbital in urine by gas chromatography chemical ionization mass spectrometry.
An accurate and sensitive g.c.m.s. procedure was developed to determine both N-hydroxyamobarbital and 3′-hydroxyamobarbital… 
1977
1977
A case of deficiency of N‐hydroxylation of amobarbital
It has been shown recently that the overall metabolism of amobarbital in man is essentially under genetic control. The drug… 
1975
1975
N-hydroxyamobarbital: the second major metabolite of amobarbital in man.
After oral administration of 14C-labeled amobarbital to healthy subjects, most of the radioactivity was recovered in urine and… 
1974
1974
(2-14C) amobarbital metabolism in tolerant rats.
1. Comparative studies on the distribution and metabolism of [2-14C]amobarbital following 50 mg/kg intraperitoneal doses in non… 
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