FAQ

3,4-dichloroisocoumarin

Known as: 3,4-DCL 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1985-2013
051019852013

Related topics

Related topics

2 relations

Broader (2)

CoumarinsSerine Proteinase Inhibitors

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
3,4-dichloroisocoumarin
Serine Proteinase Inhibitors
Coumarins

Papers overview

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2012
2012
Catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate.
Rhomboid proteases have many important biological functions. Unlike soluble serine proteases such as chymotrypsin, the active… (More)
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Highly Cited
2006
Highly Cited
2006
Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC.
BACKGROUND/AIMS We have investigated the role of natural killer (NK) cells in hepatic fibrogenesis. Mouse NK cells express both… (More)
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Highly Cited
2004
Highly Cited
2004
Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes
AbstractErythrocytes lack nuclei and mitochondria, the organelles important for apoptosis of nucleated cells. However, following… (More)
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Highly Cited
1998
Highly Cited
1998
Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix.
Cathepsin K (EC 3.4.22.38) is a recently described enzyme that has been shown to cleave type I collagen in its triple helix. The… (More)
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1997
1997
Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both…
The human leukemia cell line, HL60 is very sensitive to various apoptotic stimuli and p53-null. The death-related cysteine… (More)
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Highly Cited
1996
Highly Cited
1996
Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate.
Until recently, the degradation of aberrant and unassembled proteins retained in the endoplasmic reticulum (ER) was thought to… (More)
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Highly Cited
1995
Highly Cited
1995
Proteasome from Thermoplasma acidophilum: a threonine protease.
The catalytic mechanism of the 20S proteasome from the archaebacterium Thermoplasma acidophilum has been analyzed by site… (More)
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1992
1992
A 3,4-dichloroisocoumarin-resistant component of the multicatalytic proteinase complex.
The multicatalytic proteinase complex (MPC) exhibits three proteolytic activities designated as trypsin-like, chymotrypsin-like… (More)
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Highly Cited
1992
Highly Cited
1992
A natural killer cell granule protein that induces DNA fragmentation and apoptosis
We report the purification from a rat natural killer (RNK) large granular lymphocyte leukemia of a 32-kD granule protein that… (More)
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1985
1985
Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor.
The mechanism-based inactivations of a number of serine proteases, including human leukocyte (HL) elastase, cathepsin G, rat mast… (More)
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