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3,4-dichloroisocoumarin

Known as: 3,4-DCL 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

CoumarinsSerine Proteinase Inhibitors

Papers overview

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Highly Cited
2006
Highly Cited
2006
Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC.
Highly Cited
1996
Highly Cited
1996
Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate.
Highly Cited
1995
Highly Cited
1995
Proteasome from Thermoplasma acidophilum: a threonine protease.
The catalytic mechanism of the 20S proteasome from the archaebacterium Thermoplasma acidophilum has been analyzed by site… 
Highly Cited
1994
Highly Cited
1994
Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes.
Highly Cited
1993
Highly Cited
1993
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched…
Initial studies on the specificity of the multicatalytic proteinase complex (MPC; EC 3.4.99.46) led to the identification of… 
Highly Cited
1992
Highly Cited
1992
Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms.
Highly Cited
1992
Highly Cited
1992
A natural killer cell granule protein that induces DNA fragmentation and apoptosis
We report the purification from a rat natural killer (RNK) large granular lymphocyte leukemia of a 32-kD granule protein that… 
Highly Cited
1987
Highly Cited
1987
Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates.
Highly Cited
1986
Highly Cited
1986
Red blood cells contain a pathway for the degradation of oxidant-damaged hemoglobin that does not require ATP or ubiquitin.
Highly Cited
1985
Highly Cited
1985
Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor.
The mechanism-based inactivations of a number of serine proteases, including human leukocyte (HL) elastase, cathepsin G, rat mast… 
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