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3,4-dichloroisocoumarin

Known as: 3,4-DCL 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

CoumarinsSerine Proteinase Inhibitors

Papers overview

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2011
2011
Catalytic Mechanism of Rhomboid Protease GlpG Probed by 3,4-Dichloroisocoumarin and Diisopropyl Fluorophosphonate*
  • Yi Xue, Ya Ha
  • The Journal of Biological Chemistry
  • 2011
    • Corpus ID: 1553205
Background: The rhomboid protease GlpG is a prototype of the serine intramembrane protease. Results: The crystal structure of… Expand
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Highly Cited
2006
Highly Cited
2006
Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC.
BACKGROUND/AIMS We have investigated the role of natural killer (NK) cells in hepatic fibrogenesis. Mouse NK cells express both… Expand
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Highly Cited
2004
Highly Cited
2004
Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes
AbstractErythrocytes lack nuclei and mitochondria, the organelles important for apoptosis of nucleated cells. However, following… Expand
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Highly Cited
1999
Highly Cited
1999
The Human Cytotoxic T Cell Granule Serine Protease Granzyme H Has Chymotrypsin-like (Chymase) Activity and Is Taken Up into Cytoplasmic Vesicles Reminiscent of Granzyme B-containing Endosomes*
Serine proteases (granzymes) contained within the cytoplasmic granules of cytotoxic T cells and natural killer cells play a… Expand
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Highly Cited
1998
Highly Cited
1998
Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix.
Cathepsin K (EC 3.4.22.38) is a recently described enzyme that has been shown to cleave type I collagen in its triple helix. The… Expand
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Highly Cited
1997
Highly Cited
1997
Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9.
In general, inflammatory cells cross basement membranes by producing proteinases. To investigate the role of proteinases in… Expand
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Highly Cited
1995
Highly Cited
1995
Proteasome from Thermoplasma acidophilum: a threonine protease.
The catalytic mechanism of the 20S proteasome from the archaebacterium Thermoplasma acidophilum has been analyzed by site… Expand
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Highly Cited
1993
Highly Cited
1993
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched…
Initial studies on the specificity of the multicatalytic proteinase complex (MPC; EC 3.4.99.46) led to the identification of… Expand
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Highly Cited
1992
Highly Cited
1992
A natural killer cell granule protein that induces DNA fragmentation and apoptosis
We report the purification from a rat natural killer (RNK) large granular lymphocyte leukemia of a 32-kD granule protein that… Expand
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Highly Cited
1985
Highly Cited
1985
Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor.
The mechanism-based inactivations of a number of serine proteases, including human leukocyte (HL) elastase, cathepsin G, rat mast… Expand
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