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3,4-dichloroisocoumarin
Known as:
3,4-DCL
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Coumarins
Serine Proteinase Inhibitors
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC.
A. Melhem
,
N. Muhanna
,
+7 authors
R. Safadi
Journal of Hepatology
2006
Corpus ID: 31867831
Highly Cited
1996
Highly Cited
1996
Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate.
E. Werner
,
J. Brodsky
,
A. McCracken
Proceedings of the National Academy of Sciences…
1996
Corpus ID: 3089011
Highly Cited
1995
Highly Cited
1995
Proteasome from Thermoplasma acidophilum: a threonine protease.
E. Seemüller
,
A. Lupas
,
D. Stock
,
J. Löwe
,
R. Huber
,
W. Baumeister
Science
1995
Corpus ID: 21972308
The catalytic mechanism of the 20S proteasome from the archaebacterium Thermoplasma acidophilum has been analyzed by site…
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Highly Cited
1994
Highly Cited
1994
Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes.
A. Vinitsky
,
C. Cardozo
,
L. Sepp-Lorenzino
,
C. Michaud
,
M. Orłowski
Journal of Biological Chemistry
1994
Corpus ID: 9160102
Highly Cited
1993
Highly Cited
1993
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched…
M. Orłowski
,
C. Cardozo
,
C. Michaud
Biochemistry
1993
Corpus ID: 22468082
Initial studies on the specificity of the multicatalytic proteinase complex (MPC; EC 3.4.99.46) led to the identification of…
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Highly Cited
1992
Highly Cited
1992
Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms.
A. Pandiella
,
M. Bosenberg
,
E. Huang
,
P. Besmer
,
J. Massagué
Journal of Biological Chemistry
1992
Corpus ID: 33606135
Highly Cited
1992
Highly Cited
1992
A natural killer cell granule protein that induces DNA fragmentation and apoptosis
L. Shi
,
R. Kraut
,
R. Aebersold
,
A. Greenberg
Journal of Experimental Medicine
1992
Corpus ID: 17236329
We report the purification from a rat natural killer (RNK) large granular lymphocyte leukemia of a 32-kD granule protein that…
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Highly Cited
1987
Highly Cited
1987
Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates.
L. Waxman
,
J. Fagan
,
A. Goldberg
Journal of Biological Chemistry
1987
Corpus ID: 21915765
Highly Cited
1986
Highly Cited
1986
Red blood cells contain a pathway for the degradation of oxidant-damaged hemoglobin that does not require ATP or ubiquitin.
J. Fagan
,
L. Waxman
,
A. Goldberg
Journal of Biological Chemistry
1986
Corpus ID: 10487571
Highly Cited
1985
Highly Cited
1985
Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor.
J. Harper
,
K. Hemmi
,
J. Powers
Biochemistry
1985
Corpus ID: 374764
The mechanism-based inactivations of a number of serine proteases, including human leukocyte (HL) elastase, cathepsin G, rat mast…
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