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2-ethynylnaphthalene

National Institutes of Health

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Naphthalenes

Papers overview

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Highly Cited
2013
Highly Cited
2013
Formation mechanism of polycyclic aromatic hydrocarbons beyond the second aromatic ring.
The formation mechanism of polycyclic aromatic hydrocarbons (PAH) with three fused aromatic rings starting from naphthalene has… 
Highly Cited
2009
Highly Cited
2009
A detailed kinetic modeling study of toluene oxidation in a premixed laminar flame.
1996
1996
Mechanism-based inhibition of mouse P4502b-10 by selected arylalkynes.
1996
1996
A role for threonine 302 in the mechanism-based inactivation of P450 2B4 by 2-ethynylnaphthalene.
2-Ethynylnaphthalene (2EN) is a mechanism-based inactivator of P450 2B4 that covalently modifies an amino acid in the peptide… 
1994
1994
Identification of active-site peptides from 3H-labeled 2-ethynylnaphthalene-inactivated P450 2B1 and 2B4 using amino acid sequencing and mass spectrometry.
2-Ethynylnaphthalene (2EN) is a mechanism-based inactivator of rat cytochrome P450 (P450) 2B1 with 1.3 mol of adduct bound per… 
1993
1993
Mechanism-based inactivation of cytochrome P450 2B1 by 2-ethynylnaphthalene: identification of an active-site peptide.
The 7-ethoxycoumarin O-deethylase activity of rat liver cytochrome P450 2B1 reconstituted with NADPH-cytochrome P450 reductase… 
1993
1993
Cytochrome P4501A1 mediates the metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat and human.
Previous studies have established that TCDF is rapidly metabolized and excreted in rats and that pretreatment of rats with TCDD… 
Highly Cited
1992
Highly Cited
1992
Suicide inhibitors of cytochrome P450 1A1 and P450 2B1.
1992
1992
Modification of cytochrome P450 1A2 enzymes by the mechanism-based inactivator 2-ethynylnaphthalene and the photoaffinity label 4-azidobiphenyl.
2-Ethynylnaphthalene (2EN) had previously been demonstrated to be a mechanism-based inactivator of rat cytochrome P450 (P450) 1A2… 
1989
1989
2-ethynylnaphthalene as a mechanism-based inactivator of the cytochrome P-450 catalyzed N-oxidation of 2-naphthylamine.
Since the N-oxidation of several carcinogenic arylamines has been shown to be catalyzed preferentially by cytochrome P-450IA2 in… 
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