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2-amino-2-deoxyisochorismate

National Institutes of Health

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Cyclohexanecarboxylic Acids

Papers overview

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2014
2014
The fused anthranilate synthase from Streptomycesvenezuelae functions as a monomer
Recently, we showed that the fused chorismate-utilizing enzyme from the antibiotic-producing soil bacterium Streptomyces… Expand
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2012
2012
Structure of aminodeoxychorismate synthase from Stenotrophomonas maltophilia.
PabB, aminodeoxychorismate synthase, is the chorismic acid binding component of the heterodimeric PabA-PabB complex that converts… Expand
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2009
2009
2-Amino-2-deoxyisochorismate is a key intermediate in Bacillus subtilis p-aminobenzoic acid biosynthesis.
Chorismate is an important and central metabolite branching off to the biosyntheses of aromatic amino acids and p-aminobenzoic… Expand
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2008
2008
Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027.
C-1027 is a potent antitumor antibiotic composed of an apoprotein (CagA) and a reactive enediyne chromophore. The chromophore has… Expand
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2008
2008
Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism
C-1027 is an enediyne antitumor antibiotic composed of four distinct moieties: an enediyne core, a deoxy aminosugar, a β-amino… Expand
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2008
2008
The fused TrpEG from Streptomyces venezuelae is an anthranilate synthase, not a 2-amino-2-deoxyisochorismate [corrected] (ADIC) synthase.
The chloramphenicol producer Streptomyces venezuelae contains an enzyme, SvTrpEG, that has a high degree of amino acid sequence… Expand
2007
2007
Nucleophile Selectivity of Chorismate‐Utilizing Enzymes
aeruginosa) catalyzes the conversion of chorismate to isochorismate (2) by nucleophilic addition of water to the C2 of chorismate… Expand
Highly Cited
2004
Highly Cited
2004
Conservation of mechanism in three chorismate-utilizing enzymes.
Chorismate is the end-product of the shikimate pathway for biosynthesis of carbocyclic aromatic compounds in plants, bacteria… Expand
Highly Cited
2003
Highly Cited
2003
Structure and mechanism of Pseudomonas aeruginosa PhzD, an isochorismatase from the phenazine biosynthetic pathway.
PhzD from Pseudomonas aeruginosa is an isochorismatase involved in phenazine biosynthesis. Phenazines are antimicrobial compounds… Expand
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