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2-Isopropylmalate Synthase

Known as: alpha-Isopropylmalate Synthase, 3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating), Synthase, alpha-Isopropylmalate 
An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric… 
National Institutes of Health

Related topics

Related topics

9 relations
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Narrower (2)

LEU4 protein, S cerevisiaeLEU9 protein, S cerevisiae

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Mapping of the allosteric network in the regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis by the feedback inhibitor L-leucine: solution-phase H/D exchange monitored by FT…
As it is becoming accepted that allosteric regulation can occur through a change in local conformational equilibria as opposed to… 
2000
2000
Identification by functional analysis of the gene encoding α‐isopropylmalate synthase II (LEU9) in Saccharomyces cerevisiae
The function of the open reading frame (ORF) YOR108w of Saccharomyces cerevisiae has been analysed. The deletion of this ORF from… 
1995
1995
Additive Activation of Yeast LEU4 Transcription by Multiple cis Elements (*)
The LEU4 gene of Saccharomyces cerevisiae and the enzyme encoded by LEU4, α-isopropylmalate synthase, occupy a special position… 
1994
1994
Regulation of tryptophan biosynthesis in Methanobacterium thermoautotrophicum Marburg
A tryptophan-auxotrophic mutant of the archaeon Methanobacterium thermoautotrophicum Marburg was grown with growth-promoting and… 
1991
1991
The N-terminal and C-terminal portions of NifV are encoded by two different genes in Clostridium pasteurianum
The nifV gene products from Azotobacter vinelandii and Klebsiella pneumoniae share a high level of primary sequence identity and… 
1985
1985
Total deletion of yeast LEU4: further evidence for a second alpha-isopropylmalate synthase and evidence for tight LEU4-MET4 linkage.
1983
1983
Transcription initiation sites of the leucine operons of Salmonella typhimurium and Escherichia coli.
1981
1981
Inactivation of yeast alpha-isopropylmalate synthase by CoA. Antagonism between CoA and adenylates and the mechanism of CoA inactivation.
1980
1980
alpha-Isopropylmalate synthase from yeast. A zinc metalloenzyme.
1979
1979
Biosynthesis of Kitasamycin(Leucomycin) by Leucine Analog-Resistant Mutants of Streptomyces kitasatoensis
The biosynthesis of kitasamycin in Streptomyces kitasatoensis B-896 was profoundly influenced by the addition of precursors to… 
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